Sulfur Rich Natural Substances

Name	AC	CK
Oxidative Stress	37	113
Prostate Cancer	24	79
Bladder Cancer	12	61
Prostate Cancer: Prevention	9	61
Pancreatic Cancer	14	57
Helicobacter Pylori Infection	6	48
Cancers: All	16	47
Inflammation	14	45
Breast Cancer	25	44
Diabetes Mellitus: Type 2: Prevention	2	40
DNA damage	10	33
Lung Cancer	9	33
Athletic Performance: Recovery	3	30
Osteoarthritis	3	30
Ovarian Cancer	4	27
Colorectal Cancer	5	26
Colon Cancer	12	23
Hypertension	2	22
HDL: Low	3	21
Lung Cancer: Prevention	3	21
Skin Diseases	2	21
Digestive System Neoplasms	1	20
Endothelial Dysfunction	5	20
Fatty Liver	1	20
Gastritis	1	20
Kidney Cancer: Prevention	1	20
Metabolic Syndrome X	2	20
Prostate: PSA Doubling	2	20
Schizophrenia	2	20
Aging	4	17
Immune Disorders: Low Immune Function	4	15
Cognitive Decline/Dysfunction	3	14
Liver Cancer	12	14
Breast Cancer: Prevention	3	13
Cancer Metastasis	9	13
Cancers: Drug Resistant	4	13
Cardiovascular Diseases	3	13
Petroleum Exposure And Toxicity	3	13
Diabetes Mellitus: Type 2	3	12
Diesel Exhaust Particle Toxicity	3	12
Glutathione Deficiency	3	12
Insulin Resistance	2	12
Smoking	2	12
Retinal Diseases	2	11
Air Pollution Linked Toxicity	1	10
Allergic Rhinitis	1	10
Anemia: Sickle Cell	1	10
Asthma	1	10
Athletic Performance	1	10
Autism Spectrum Disorders	1	10
Bladder Degeneration	1	10
C-Reactive Protein	1	10
COPD	1	10
Cystic Fibrosis	1	10
Esophageal Cancer	1	10
Fibroids: Uterine	1	10
Fibromyalgia	1	10
Food Allergy: Egg	1	10
Gastroesophageal Reflux	1	10
Herpes family viruses	1	10
High Cholesterol	1	10
Human Papillomavirus (HPV)	1	10
Hyperinsulinism	1	10
Hyperlipidemia	1	10
Hyperlipidemia: Familial Combined	1	10
Influenza in Swine	1	10
Interstitial Lung Diseases	1	10
Lung Diseases	1	10
Lymphopenia	1	10
Neutrophils: Elevated	1	10
Osteoarthritis: Knee	1	10
Pulmonary Fibrosis	1	10
Radical Prostatectomy	1	10
Respiratory Diseases	1	10
Rosacea	1	10
Smoke Inhalation Poisoning	1	10
Swine Flu Associated Virus	1	10
Thrush	1	10
Chemotherapy-Induced Toxicity: Cisplatin	5	9
Cancer Stem Cells	6	8
Lipopolysaccharide-Induced Toxicity	6	8
Melanoma	4	8
Gastric Cancer	3	7
Adenomatous Polyposis Coli	3	6
Chemically-Induced Liver Damage	4	6
Leukemia	6	6
Neurodegenerative Diseases	4	6
Aging Skin	2	5
Cerebral Ischemia	3	5
Endothelial Damage	1	5
Enterococcus Infections	1	5
Graying Hair	1	5
Hypoxia	4	5
Melanoma: Metastatic	2	5
Myocardial Ischemia	3	5
Skin Diseases: Photo-Aging	2	5
Aflatoxicosis	3	4
Bacterial Infections and Mycoses	2	4
Brain Injury: Traumatic	2	4
Brain: Microglial Activation	2	4
Breast Cancer: Metastatic	3	4
Chemotherapy-Induced Toxicity: Doxorubicin	3	4
Intestinal Polyps	2	4
Light Sensitivity	1	4
Obesity	2	4
Organ Transplantation: Pancreatic Islet Cells	2	4
Skin Cancer: Prevention	2	4
Spinal Cord Injuries	2	4
Traumatic Brain Injury	2	4
Tumors	2	4
Benzo[a]pyrene-induced Toxicity	2	3
Blood-Brain-Barrier Disorders	2	3
Brain Cancer	3	3
Brain Damage	2	3
Brain Inflammation	2	3
Cadmium Poisoning	2	3
Candida Infection	3	3
Carcinoma: Non-Small-Cell Lung	2	3
Cervical Cancer	3	3
Chemotherapy-Induced Toxicity	2	3
Colon Cancer: Prevention	2	3
Diabetes Mellitus: Type 1: Prevention	2	3
Diabetic Nephropathy	2	3
Fungal Infection	1	3
Glioblastoma	3	3
Intestinal Diseases	2	3
Liver Cancer: Prevention	2	3
Liver Damage: Aflatoxin-Induced	2	3
Low Disorders: Low TH1	2	3
Lymphoma	2	3
Multiple Myeloma	2	3
Myocardial Infarction	2	3
Oral Cancer	2	3
Osteosarcoma	2	3
Parkinson's Disease	3	3
Polycyclic aromatic hydrocarbon (PAH) toxicity	2	3
Promyelocytic leukemia	3	3
Rheumatoid Arthritis	2	3
Skin Cancer	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Advanced Glycation End products (AGE)	1	2
Alzheimer's Disease	2	2
Amebiasis	1	2
Amphetamine Addiction/Withdrawal	1	2
Anxiety Disorders	1	2
Arterial Calcification	1	2
Arterial Plaque	1	2
Arterial Thickening	1	2
Arteriosclerosis	1	2
Aspirin-Induced Toxicity	1	2
Atherosclerosis	1	2
Brain Edema	1	2
Brain Hypoxia	2	2
Cancers: Multi-Drug Resistant	1	2
Cataract	1	2
Chemical Exposure	1	2
Chemical Weapon Agent Injury	1	2
Cholesterol: Oxidation	1	2
Colitis	1	2
Colorectal Cancer: Prevention	1	2
Cyanide Poisoning	1	2
Depression	1	2
Diabetes Mellitus: Type 1	1	2
Diabetic Complications	1	2
Dioxin Toxicity	1	2
Duchenne's Muscular Dystrophy	1	2
Encephalomyelitis	1	2
Endotoxemia	1	2
Epstein-Barr Virus Infections	1	2
Fluoride Toxicity	1	2
Furan Toxicity	1	2
Gastric Ulcer	1	2
Gastrointestinal Cancer	1	2
Glioma	2	2
Gout	1	2
Head and Neck Cancer	2	2
Hypertension: Pulmonary	1	2
Hypoglycemia	2	2
Immune Dysregulation: TH1/TH2 imbalance	1	2
Infertility: Female	1	2
Intima Media Thickening	1	2
Intoxication	1	2
Kidney Diseases	1	2
Lead Poisoning	1	2
Learning disorders	1	2
Liver Disease	1	2
Liver Disease: Oxidative Stress	1	2
Low Immune Function: Natural Killer Cells	1	2
Malathion Toxicity	1	2
Memory Disorders	1	2
Mercury Poisoning	1	2
Multiple Sclerosis	1	2
Muscle Damage: Exercise-Induced	1	2
Muscle Fatigue	1	2
Muscle Soreness	1	2
NSAID-induced toxicity	1	2
Nasopharyngeal Cancer	1	2
Nephropathy	1	2
Neurologic Disorders	1	2
Nicotine/Tobacco Toxicity	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Organ Transplantation	1	2
Respiratory Syncytial Virus Infections	1	2
Respiratory Tract Infections	1	2
Right Ventricular Hypertrophy	1	2
Salivary Gland Adenoid Cystic Carcinoma.	2	2
Salivary Gland Diseases	2	2
Seizures	1	2
Serotonin Disorders	1	2
Streptococcus infections: Group A	2	2
Stroke	1	2
Stroke: Recovery	1	2
Uremia	1	2
Acute lymphoblastic leukemia (ALL)	1	1
Alcoholic Liver Disease	1	1
Allergies	1	1
Androgen-Induced Diseases	1	1
Aortic Plaques	1	1
Aphthous Ulcer	1	1
Arsenic Poisoning	1	1
Benzene Toxicity	1	1
Bone Destructive Diseases: Over-Active Osteoclasts	1	1
Brain Cancer Stem Cells	1	1
Brain Injury: Hippocampal Damage	1	1
Breast Cancer Stem Cells	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Breast Cancer: Triple Negative	1	1
Candidiasis	1	1
Canker Sore	1	1
Cardiac Hypertrophy	1	1
Cardiovascular Disease: Prevention	1	1
Cholesterol: LDL/HDL ratio	1	1
Colon Cancer Stem Cells	1	1
Colorectal Tumors	1	1
Dental Caries	1	1
Dopamine Deficiency	1	1
Drug-Induced Toxicity	1	1
Drug-Induced Toxicity: Indomethacin	1	1
Dysbiosis: Bifidobacteria Deficiency	1	1
Dystrophic retinal detachment (DRD)	1	1
Endometrial Cancer	1	1
Excitotoxicity	1	1
Gastrointestinal Diseases	1	1
Gonorrhea	1	1
Gram-Negative Bacterial Infections	1	1
Gram-Positive Bacterial Infections	1	1
HIV Infections	1	1
Hepatitis C	1	1
Heterocyclic Aromatic Amine Induced Toxicity	1	1
High-Grade Prostatic Intraepithelial Neoplastic Lesions	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Hyperglycemia	1	1
IgE-Mediated Hypersensitivity	1	1
Kidney Damage	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Leukemia: Chronic Lymphocytic Leukemia (CLL)	1	1
Liver Cancer Stem Cells	1	1
Low Human Growth Hormone	1	1
Lymphoma: B-Cell	1	1
Lymphoma: Mantle Cell	1	1
MRSA	1	1
Macular Degeneration	1	1
Medulloblastoma	1	1
Melanism	1	1
Methicillin-resistant Staphylococcus aureus	1	1
Microcystis aeruginosa	1	1
Mitochondrial Diseases	1	1
Napthalene-Induced Toxicity	1	1
Osteoporosis: Over-active Osteoclasts	1	1
Pancreatic Cancer Stem Cell	1	1
Periodontal Diseases	1	1
Pesticide Toxicity	1	1
Pneumococcal Infections	1	1
Prediabetes	1	1
Restenosis	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Stem Cell Transplant	1	1
Stomach Cancer	1	1
Streptococcus infections: Group B	1	1
Striatonigral Degeneration: Autosomal Dominant	1	1
Sunburn	1	1
Ultraviolet Radiation Induced Damage	1	1

Name	AC	CK
Anticarcinogenic Agents	82	224
Chemopreventive	53	213
Antioxidants	57	173
Apoptotic	83	116
Anti-Inflammatory Agents	28	84
Antiproliferative	41	62
Phase II Detoxification Enzyme Inducer	14	51
Neuroprotective Agents	22	42
Nrf2 activation	16	40
Cell cycle arrest	27	35
Hepatoprotective	9	32
Glutathione Upregulation	5	22
NF-kappaB Inhibitor	18	22
Anti-Bacterial Agents	9	21
Interleukin-6 Downregulation	8	21
Anti-metastatic	15	20
Antineoplastic Agents	12	18
Enzyme Inhibitors	9	18
Histone deacetylase inhibitor	8	17
Tumor Necrosis Factor (TNF) Alpha Inhibitor	11	16
Chemotherapeutic	4	14
Cyclooxygenase 2 Inhibitors	11	14
Cytoprotective	3	14
Matrix metalloproteinase-2 (MMP-2) inhibitor	5	14
Chemosensitizer	8	12
Hypolipidemic	2	12
Genoprotective	2	11
Interleukin-1 beta downregulation	8	11
Anti-Allergic Agents	1	10
Cardioprotective	7	10
Insulin Down-Regulation	1	10
Proton Pump Inhibitor	1	10
Matrix metalloproteinase-9 (MMP-9) inhibitor	6	8
MicroRNA modulator	8	8
Anti-Angiogenic	5	7
Immunomodulatory	4	7
NF-E2-Related Factor-2 (Nrf2) Modulator	6	7
Antifungal Agents	4	6
Renoprotective	4	6
Radioprotective	2	5
Superoxide Dismutase Up-regulation	1	5
Antiviral Agents	3	4
Tumor Suppressor Protein p53 Upregulation	4	4
Anti-Proliferative	2	3
Bcl-2 protein down-regulation	3	3
Chemoprotective Agents	2	3
Proteasome Inhibitors	3	3
Wnt/β-catenin signaling pathway modulation	2	3
Acetylcholinesterase Inhibitor	1	2
Anti-Anxiety Agents	1	2
Anti-Glycation Agents	1	2
Anti-Ulcer Agents	1	2
Anticonvulsants	1	2
Antidepressive Agents	1	2
Detoxifier	2	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
Heme oxygenase-1 up-regulation	2	2
Hypotensive	1	2
Interleukin-17 downregulation	1	2
Interleukin-2 upregulation	1	2
Leptin Down-Regulation	1	2
Malondialdehyde Down-regulation	1	2
P21 Activation	2	2
Phase I Detoxification Enzyme Inducer	1	2
Prostaglandin PGE2 downregulation	1	2
Serotonergic	1	2
Telomerase Inhibitor	2	2
Angiogenesis Inhibitors	1	1
Anti-Apoptotic	1	1
Anti-Estrogenic	1	1
Antimitotic Agents	1	1
Beta-Defensin-2 Up-Regulation	1	1
Caspase-3 Activation	1	1
Cell Differentiation Inducer	1	1
Cytotoxic	1	1
DNA Repair Up-regulation	1	1
Estrogen Receptor Modulators	1	1
Interferon Gamma Reducer	1	1
Interleukin-8 downregulation	1	1
Postaglandin PGE2 downregulation	1	1
Quinone Reductase-Inducer	1	1
Radiopharmaceuticals	1	1
Radiosensitizer	1	1
Secretagogue	1	1
Survivin Down-Regulation	1	1
Vascular Cell Adhesion Molecule-1 Inhibitor	1	1
Vascular Endothelial Growth Factor Regulator	1	1
Wnt/β-catenin pathway down-regulation	1	1
anti inflammatory	1	1
anti-inflammatory	1	1

[+]

Click here to read the entire abstract

Pubmed Data : Hypertension. 2016 Feb ;67(2):288-93. Epub 2015 Dec 7. PMID: 26644239

Article Published Date : Jan 31, 2016

Study Type : Meta Analysis

Additional Links

Substances : Apples, Broccoli, Carrot, Fruit: All, Raisins, Vegetables: All

Diseases : Hypertension

Additional Keywords : Risk Reduction

[+]

Higher consumption of cruciferous vegetables is associated with a significantly decreased risk of type 2 diabetes.Jan 05, 2016

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Pubmed Data : Prim Care Diabetes. 2016 Jan 6. Epub 2016 Jan 6. PMID: 26778708

Article Published Date : Jan 05, 2016

Study Type : Meta Analysis

Additional Links

Substances : Cruciferous Vegetables

Diseases : Diabetes Mellitus: Type 2: Prevention

Additional Keywords : Risk Reduction

[+]

Higher intake of fruits, vegetables or their fiber reduces the risk of type 2 diabetesDec 31, 2015

Pubmed Data : Int J Food Sci Nutr. 2014 Feb ;65(1):106-11. Epub 2013 Sep 2. PMID: 23992556

Pubmed Data : J Pineal Res. 2006 Oct;41(3):195-200. PMID: 16948779

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 1992 Jan;12(1):28-9, 6. PMID: 1320966

Article Published Date : Jan 01, 1992

Study Type : Human Study

Additional Links

Substances : Allicin, Sodium Bicarbonate

Diseases : Thrush

[+]

Broccoli sprout homogenate is safe in stable SCD patients and may induce changes in gene expression levels.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2016 ;11(4):e0152895. Epub 2016 Apr 12. PMID: 27071063

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Substances : Broccoli Sprouts, Sulforaphane

Diseases : Anemia: Sickle Cell

Additional Keywords : Gene Expression Regulation

[+]

Broccoli sprouts may enhance detoxication of airborne pollutants and attenuate their associated health risks.Dec 31, 2011

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Pubmed Data : Carcinogenesis. 2012 Jan ;33(1):101-7. Epub 2011 Nov 1. PMID: 22045030

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Cancer. 2010 ;10:162. Epub 2010 Apr 27. PMID: 20423504

Article Published Date : Dec 31, 2009

Study Type : Human Study

Additional Links

Substances : Cruciferous Vegetables, Isothiocyanates

Diseases : Lung Cancer, Lung Cancer: Prevention, Smoking

Pharmacological Actions : Anticarcinogenic Agents

Additional Keywords : Risk Reduction

[+]

Consumption of broccoli sprouts modulated the excretion of biomarkers linked to inflammation and vascular reactions.Apr 14, 2015

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Pubmed Data : Food Chem. 2015 Apr 15 ;173:1187-94. Epub 2014 Nov 7. PMID: 25466142

Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Clin Nutr. 2015 May ;101(5):1088-96. Epub 2015 Apr 1. PMID: 25832339

Article Published Date : Apr 30, 2015

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Pubmed Data : Clin Immunol. 2009 Mar;130(3):244-51. Epub 2008 Nov 22. PMID: 19028145

Short-term egg consumption does not adversely affect endothelial function in healthy adults, supporting the view that dietary cholesterol may be less detrimental to cardiovascular health than previously thought.Mar 10, 2005

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Clin Psychopharmacol Neurosci. 2015 Apr 30 ;13(1):62-7. PMID: 25912539

Article Published Date : Apr 29, 2015

Study Type : Human Study

Additional Links

Substances : Broccoli Sprouts, Sulforaphane

Diseases : Schizophrenia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Plant Extracts, Significant Treatment Outcome

[+]

Supplementation with sulforaphane rich broccoli sprout extract could improve liver function through reduction of oxidative stress.Nov 20, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Gastroenterol. 2015 Nov 21 ;21(43):12457-67. PMID: 26604653

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Pubmed Data : Tumour Biol. 2015 Mar ;36(3):1627-42. Epub 2014 Nov 1. PMID: 25361631

Article Published Date : Feb 28, 2015

Study Type : Human Study

Additional Links

Substances : Cruciferous Vegetables

Diseases : Esophageal Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

Additional Keywords : Betel Leaf, Increased Risk, P16 Hypermethylation, Tobacco Chewing

[+]

The results of this study found that dosing twice a day may be important for increasing or prolonging certain chemopreventive benefits associated with sulforaphane consumption.Feb 28, 2015

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Pubmed Data : Mol Nutr Food Res. 2015 Mar ;59(3):424-33. Epub 2015 Jan 22. PMID: 25522265

Article Published Date : Feb 28, 2015

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Pubmed Data : Oncotarget. 2014 Mar 30 ;5(6):1621-34. PMID: 24742583

Pubmed Data : Mol Nutr Food Res. 2012 Nov ;56(11):1675-87. Epub 2012 Oct 5. PMID: 23038615

Article Published Date : Oct 31, 2012

Study Type : Animal Study

Additional Links

Substances : Erucin, Sulforaphane

Diseases : Bladder Cancer

Pharmacological Actions : Chemopreventive

[+]

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Pubmed Data : Curr Pharm Des. 2012 Aug 23. Epub 2012 Aug 23. PMID: 22950492

Article Published Date : Aug 22, 2012

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Aspirin-Induced Toxicity , NSAID-induced toxicity

[+]

3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice.Apr 01, 2005

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Pubmed Data : Carcinogenesis. 2005 Apr;26(4):771-8. Epub 2005 Jan 20. PMID: 15661811

Article Published Date : Apr 01, 2005

Study Type : Animal Study

Additional Links

Substances : Cruciferous Vegetables

Diseases : Breast Cancer, Breast Cancer: Metastatic

Pharmacological Actions : Anti-Angiogenic, Anticarcinogenic Agents

[+]

A broccoli extract enriched diet increases antioxidant enzyme activities and exerts an antioxidant effect towards cholesterol oxidation in rat liver.Apr 11, 2016

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Pubmed Data : J Steroid Biochem Mol Biol. 2016 Apr 12. Epub 2016 Apr 12. PMID: 27084531

Article Published Date : Apr 11, 2016

Study Type : Animal Study

Pubmed Data : Carcinogenesis. 2001 Nov;22(11):1871-5. PMID: 11698351

Article Published Date : Nov 01, 2001

Study Type : Animal Study

Additional Links

Substances : Folic Acid , Methionine, Vitamin B-12

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative

Anti Therapeutic Actions : Western Diet

[+]

[+]

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Pubmed Data : Am J Clin Nutr. 2009 Nov;90(5):1402-10. Epub 2009 Sep 30. PMID: 20706790

Article Published Date : Nov 01, 2009

Study Type : Animal Study

Additional Links

Substances : Broccoli, Brussel sprouts

Diseases : Myocardial Ischemia

Pharmacological Actions : Cardioprotective

[+]

dietary intake of SFN-rich broccoli sprouts during the juvenile and adolescence may prevent the onset of psychosis at adulthood. Dec 31, 2014

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Pubmed Data : PLoS One. 2015 ;10(6):e0127244. Epub 2015 Jun 24. PMID: 26107664

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Broccoli Sprouts, Sulforaphane

Diseases : Cognitive Decline/Dysfunction, Neurologic Disorders, Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation

Additional Keywords : Plant Extracts

[+]

Dimethyl trisulfide is a promising next-generation countermeasure for cyanide intoxication.Mar 02, 2016

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Pubmed Data : Toxicol Ind Health. 2016 Mar 3. Epub 2016 Mar 3. PMID: 26939832

Methionine and vitamin E inhibit sodium fluoride-induced oxidative stress in the kidney. Jan 01, 2008

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Pubmed Data : Biol Trace Elem Res. 2008 Jan;121(1):51-9. Epub 2007 Sep 18. PMID: 18186000

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Methionine, Vitamin E

Diseases : Fluoride Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

MSM has therapeutic value in an animal model of colitis. Jun 15, 2011

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Pubmed Data : Toxicol Appl Pharmacol. 2011 Jun 15 ;253(3):197-202. Epub 2011 Apr 2. PMID: 21463646

Pubmed Data : J Cell Biochem. 2016 Mar 15. Epub 2016 Mar 15. PMID: 26990292

Article Published Date : Mar 14, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Prostate Cancer

Pharmacological Actions : Chemopreventive

Additional Keywords : Cancer Stem Cells

[+]

Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.Sep 15, 2005

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Pubmed Data : Cancer Res. 2005 Sep 15;65(18):8548-57. PMID: 16166336

Article Published Date : Sep 15, 2005

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine), Phenethyl isothiocyanate, Sulforaphane

Diseases : Lung Cancer, Nicotine/Tobacco Toxicity , Smoking

Pharmacological Actions : Anticarcinogenic Agents

Additional Keywords : Isothiocyanates

[+]

Pre-treatment with sulforaphane or thymoquinone can reduce acetylsalicylic acid-induced gastric ulcers.Jun 14, 2016

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Pubmed Data : J Surg Res. 2016 Jun 15 ;203(2):348-59. Epub 2016 Mar 24. PMID: 27363643

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Pubmed Data : Breast Cancer Res Treat. 2006 Oct;99(3):333-40. Epub 2006 May 9. PMID: 16600309

Article Published Date : Oct 01, 2006

Study Type : Animal Study

Additional Links

Substances : Broccoli, Sulforaphane

Diseases : Lung Cancer, Melanoma, Melanoma: Metastatic

Pharmacological Actions : Anti-metastatic

[+]

Sulforaphane alone or in combination with other therapies may be potentially useful for glioblastoma therapy.Jan 05, 2017

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Pubmed Data : J Neurosurg. 2017 Jan 6:1-12. Epub 2017 Jan 6. PMID: 28059653

Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis.Nov 01, 2008

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Pubmed Data : Clin Cancer Res. 2008 Nov 1;14(21):6855-66. PMID: 18980980

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Article Publish Status : This is a free article. Click here to read the complete article.

Sulforaphane normalizes the kidney epigenome and improves blood pressure in hypertensive rats.Nov 03, 2011

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Pubmed Data : Am J Hypertens. 2011 Nov 3. Epub 2011 Nov 3. PMID: 22052072

Article Published Date : Nov 03, 2011

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Hypertension, Kidney Diseases

Pharmacological Actions : Hypotensive

Additional Keywords : Epigenetic Modification

[+]

Sulforaphane offers protection against angiotensin II induced testicular injury.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Nutr Biochem. 2011 Jun 16. Epub 2011 Jun 16. PMID: 21684138

Article Published Date : Jun 16, 2011

Pubmed Data : Toxicology. 2011 Aug 15 ;286(1-3):20-7. Epub 2011 May 6. PMID: 21575670

Article Published Date : Aug 15, 2011

Sulforphane attenuates oxidative stress and neuronal damage following traumatic brain injury. Oct 18, 2010

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Pubmed Data : Acta Pharmacol Sin. 2010 Oct 18. Epub 2010 Oct 18. PMID: 20953205

Article Published Date : Oct 18, 2010

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Brain Injury: Traumatic, Traumatic Brain Injury

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

The flavonoid fraction of broccoli inhibits selenite-induced cataract formation in an animal model.Feb 01, 2010

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Pubmed Data : Curr Eye Res. 2010 Feb;35(2):99-107. PMID: 20136419

Article Published Date : Feb 01, 2010

Study Type : Animal Study

Additional Links

Substances : Broccoli, Flavonoids

Diseases : Cataract

Pharmacological Actions : Antioxidants

Additional Keywords : Plant Extracts, Sodium Selenite

[+]

This study supports the hypothesis that a diet rich in tomato and broccoli can reduce or prevent dietary carcinogen induced cancers.Dec 31, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2013 ;8(11):e79842. Epub 2013 Nov 27. PMID: 24312188

Article Published Date : Dec 31, 2012

Study Type : Animal Study

Additional Links

Substances : Broccoli, Tomato

Diseases : Breast Cancer, Cancers: All, Colorectal Cancer: Prevention , Prostate Cancer: Prevention

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

Additional Keywords : Dietary Concentrations, Dietary Modification

Problem Substances : Meat: Cooked

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Thymoquinone and Nigella sativa oil protection against methionine-induced hyperhomocysteinemia in rats.Dec 31, 2003

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Pubmed Data : Int J Cardiol. 2004 Jan ;93(1):19-23. PMID: 14729430

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Pubmed Data : Cell Biochem Biophys. 2012 Jul ;63(3):247-59. PMID: 22565590

A combination of benzyl isothiocyanate and sulforaphane have potent inhibitory activity in pancreatic cancer cells.Dec 01, 2002

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Pubmed Data : Int J Cardiol. 2002 Dec;86(2-3):317-23. PMID: 19712481

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Curr Med Chem. 2011 ;18(22):3306-13. PMID: 21728972

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Pubmed Data : J Antibiot (Tokyo). 2009 Dec;62(12):691-7. Epub 2009 Oct 30. PMID: 19876074

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Pubmed Data : J Med Food. 2011 May 6. Epub 2011 May 6. PMID: 21548800

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2016 ;8(9). Epub 2016 Sep 6. PMID: 27608040

Article Published Date : Dec 31, 2015

Study Type : Review

Additional Links

Substances : Apples, Broccoli, Fruit: All, Onion, Polyphenols, Vegetables: All

Diseases : Breast Cancer

Therapeutic Actions : Dietary Modification: Mediterranean Diet

Pharmacological Actions : Chemopreventive

Additional Keywords : Risk Reduction

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Benzyl isothiocyanate (BITC), a constituent of edible cruciferous vegetables, induces cell cycle arrest and death in human breast cancer cells. Nov 01, 2006

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Pubmed Data : Mol Cancer Ther. 2006 Nov;5(11):2931-45. PMID: 17121941

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Pubmed Data : J Nutr Biochem. 2017 Jan 12 ;42:72-83. Epub 2017 Jan 12. PMID: 28131897

Article Published Date : Jan 11, 2017

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Prostate Cancer

Pharmacological Actions : Chemopreventive, MicroRNA modulator

Additional Keywords : Gene Expression Regulation

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Collard greens, kale and Chinese broccoli have a wide range of phenolic components.Aug 26, 2009

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Pubmed Data : J Agric Food Chem. 2009 Aug 26;57(16):7401-8. PMID: 19627150

Article Published Date : Aug 26, 2009

Study Type : In Vitro Study

Additional Links

Substances : Broccoli, Collards, Flavonoids, Kale

Additional Keywords : Plant Extracts

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Combination of photodynamic therapy and Sulforaphane led to enhanced cytotoxic effect on head and neck cancer cells.Dec 31, 2014

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Pubmed Data : Gen Physiol Biophys. 2015 Jan ;34(1):13-21. Epub 2014 Nov 14. PMID: 25395599

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Pubmed Data : Nutr Cancer. 2015 Jul 2:1-11. Epub 2015 Jul 2. PMID: 26134366

Article Published Date : Jul 01, 2015

Study Type : In Vitro Study

Additional Links

Substances : Erucin, Sulforaphane

Diseases : Breast Cancer: HER-2 Overexpressed

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Drug: Allopurinol, Isothiocyanates, Natural Substance/Drug Synergy

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Cyclin D1 is an important determinant of the therapeutic efficiency of Sulforaphane in A549 cells.May 31, 2016

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Pubmed Data : Int J Oncol. 2016 Jun ;48(6):2521-33. Epub 2016 Mar 18. PMID: 27035641

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Curr Pharmacol Rep. 2015 May ;1(3):179-196. Epub 2015 Jan 30. PMID: 26457242

Article Published Date : Apr 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Indole-3-Carbinol, Phenethyl isothiocyanate, Sulforaphane

Diseases : Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemopreventive, MicroRNA modulator, Nrf2 activation

Additional Keywords : DNA Methylation

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Incorporation of an epigenetic diet may in fact be the key to chemoprevention.Jan 31, 2015

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Pubmed Data : Curr Pharmacol Rep. 2015 Feb 1 ;1(1):46-51. PMID: 25774338

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Pubmed Data : Oncol Rep. 2015 Sep 18. Epub 2015 Sep 18. PMID: 26397194

Article Published Date : Sep 17, 2015

Study Type : In Vitro Study

Additional Links

Substances : Isothiocyanates, Sulforaphane

Diseases : Glioma

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Methylsulfonylmethane has anti-inflammatory effects against lipopolysaccharide-induced inflammatory responses in murine macrophages.Apr 01, 2009

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Pubmed Data : Biol Pharm Bull. 2009 Apr ;32(4):651-6. PMID: 19336900

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Pubmed Data : Cancer Res. 2015 Nov 5. Epub 2015 Nov 5. PMID: 26542215

Article Published Date : Nov 04, 2015

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The Following are Sub-Topics of Sulfur Rich Natural Substances

View the Evidence: 429 Abstracts with Sulfur Rich Natural Substances Research

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Associations show no clear association between egg intake and increased or decreased risk of coronary heart disease.Oct 05, 2016

Consumption of cruciferous vegetables may reduce the risk of ovarian cancer.Dec 31, 2014

Cruciferous vegetable intake might be inversely associated with the incidence of pancreatic cancer. Dec 31, 2014

Cruciferous vegetables intake is related to the decreased risk of prostate cancer.Jan 31, 2012

Evidence exists indicating that Brassica vegetables reduce prostate cancer risk.Jan 01, 2002

Greater long-term intake and increased consumption of whole fruits may reduce the risk of developing hypertension.Jan 31, 2016

Higher consumption of cruciferous vegetables is associated with a significantly decreased risk of type 2 diabetes.Jan 05, 2016

Higher intake of fruits, vegetables or their fiber reduces the risk of type 2 diabetesDec 31, 2015

The consumption of eggs has a protective effect against bladder cancer in the Japanese.Oct 31, 2012

This meta-analysis study found a high daily intake of green leafy vegetables significantly reduced incidence of several types of CVD.Dec 31, 2015

This meta-analysis suggested that high intake of cruciferous vegetables was inversely associated with renal cell carcinoma risk among Americans.Dec 31, 2012

This study provides support that cruciferous vegetable intake protects against cancer of the colon and the significance of gene diet interactions.Dec 31, 2013

"Whole egg consumption improves lipoprotein profiles and insulin sensitivity to a greater extent than yolk-free egg substitute in individuals with metabolic syndrome."Sep 25, 2012

10-day broccoli consumption has a significant effect on the inflammatory status of young healthy smokers.Jan 31, 2014

A combination of ascorbigen (a food derived form of vitamin c) and broccoli powder reduces pain sensivitiy and improves quality of life in patients with fibromyalgia. Oct 01, 2000

A combination of coenzyme10, vitamin E, selenium, methionine and phospholipids protects against occupational and environmental stress in workers of the gas and oil industry. Jan 01, 2003

A dietary supplement containing melatonin, l-tryptophan, vitamin B6, folic acid, vitamin B12, methionine and betaine, is superior to omeprazole in treating GERD. Oct 01, 2006

A greater intake of fresh fruits and cruciferous vegetables may be able to reduce the incidence of uterine fibroids.Oct 11, 2015

A human clinical study demonstrates that diets rich in cruciferous vegetables may reduce the risk of prostate cancer.Jan 01, 2008

A polyphenol-rich whole food supplement significantly effected the rate of PSA progression among men with prostate cancer.Mar 10, 2014

Acetylcysteine is beneficial in treating idiopathic pulmonary fibrosis. - Article 2Sep 01, 1995

After 4 weeks consuming broccoli sprouts powder it resulted in a significant decrease in serum insulin concentration in patients. Oct 31, 2012

Allicin extract and sodium bicarbonate may be suitable as drug alternatives in prevention of thrush in newborn infants. Jan 01, 1992

Broccoli sprout homogenate is safe in stable SCD patients and may induce changes in gene expression levels.Dec 31, 2015

Broccoli sprouts may enhance detoxication of airborne pollutants and attenuate their associated health risks.Dec 31, 2011

Broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Apr 01, 2009

Co-consuming cooked whole eggs is an effective way to enhance carotenoid absorption from other carotenoid-rich foods.May 26, 2015

Coenzyme Q(10), vitamin E, selenium, and methionine in the treatment of chronic recurrent viral mucocutaneous infections.Nov 11, 2011

Consumption of a diet rich in cruciferous vegetables may reduce the risk of lung cancer among smokers.Dec 31, 2009

Consumption of broccoli sprouts modulated the excretion of biomarkers linked to inflammation and vascular reactions.Apr 14, 2015

Consumption of cruciferous and apiaceous vegetables reduced circulating IL-6.Oct 31, 2014

Consumption of fruit and vegetables-particularly cruciferous and green leafy vegetables, citrus fruit and juice reduced ischemic stroke risk.Oct 05, 1999

Consumption of fruit or fiber-fruit decreases the risk of cardiovascular disease.Mar 16, 2017

consumption of specific green leafy vegetables and other vegetables might be associated with a reduced risk of lung cancer. Dec 31, 2013

Cruciferous vegetable consumption was strongly associated with reduced risk of prostate cancer progression.Jun 30, 2012

Cruciferous vegetable intake may be associated with a reduction in lung cancer risk among men who are currently nonsmokers.Apr 04, 2017

Cystine (a dipeptide of cysteine) and theanine supplementation restores high-Intensity resistance exercise-induced atenuation of natural killer cell activity in well-trained men.Feb 09, 2010

Daily administration of free sulforaphane shows promise in managing biochemical recurrences in prostate cancer after radical prostatectomy.May 11, 2015

Daily consumption of a lutein-enriched egg drink for one year leads to a significant increase in visual acuity.Dec 31, 2015

Data from a series of case control studies suggested a favourable role of high intakes of fruit and vegetables in the risk of many common cancers, particularly of the digestive tract.Mar 31, 2015

Dietary baked egg accelerates resolution of egg allergy in children.Jul 31, 2012

Egg consumption increases HDL-c levels in healthy young people. Mar 01, 2008

Egg consumption was found to be non-detrimental to endothelial function and serum lipids in hyperlipidemic adults.Jan 01, 2010

Egg intake improves carotenoid status by increasing plasma HDL cholesterol in adults with metabolic syndrome.Nov 04, 2012

Eggshell membrane significantly reduced both joint pain and stiffness in patients with osteoarthritis of the knee. Aug 01, 2009

Evidence from two independent human studies indicates that consumption of high glucoraphanin broccoli significantly reduces plasma LDL-C.Apr 30, 2015

Greater vegetable and fruit intake is associated with a lower risk of breast cancer among Chinese women.Jul 01, 2009

High cruciferous vegetable consumption may reduce bladder cancer risk. Apr 07, 1999

Higher egg intake was associated with a lower risk of T2D in this cohort of middle-aged and older men.Apr 30, 2015

Higher methionine intake may reduce the risk of pancreatic cancer. Jan 01, 2007

L-cystine and l-theanine may contribute to enhancing the immune response against the H1N1 virus. Dec 01, 2008

MSM contributes to the improvement of the symptoms of rosacea.Mar 01, 2008

MSM improves symptoms of pain and physical function in those with osteoarthritis.Mar 01, 2006

MSM relieves symptoms in the treatment of seasonal allergic rhinitis.Apr 01, 2002

MSM supplementation has therapeutic value in osteoarthritis. Jan 01, 2011

N-acetyl cysteine appears to be a safe and moderately effective augmentation strategy in chronic schizophrenia.Sep 01, 2008

Oral broccoli sprouts have significant therapeutic value in the treatment of Helicobacter pylori infection. Aug 01, 2004

Oral sulforaphane safely and effectively induces mucosal Phase II enzyme expression in the upper airway of human subjects. Mar 01, 2009

Oral supplementation of MSM has alleviating effects on known markers of oxidative stress following acute bouts of exercise in healthy young men.Oct 01, 2011

Our data strongly support that high vegetable consumption, especially cruciferous vegetable intake, may protect against bladder cancer. Jul 01, 2009

Pre diagnostic cruciferous vegetables intake is associated with better survival of lung cancer in Chinese women. Dec 31, 2014

Raw broccoli results in faster absorption, higher bioavailability, and higher peak plasma amounts of sulforaphane, compared to cooked broccoli.Nov 26, 2008

Safety Study: Brocolli sprouts (sulforaphane) are safe, tolerable and do not adversely effect thyroid hormone levels.Jan 01, 2006

Serum levels of vitamin B(6) and methionine were inversely associated with risk of lung cancer.Jun 15, 2010

Short-term egg consumption does not adversely affect endothelial function in healthy adults, supporting the view that dietary cholesterol may be less detrimental to cardiovascular health than previously thought.Mar 10, 2005

Sulforaphane has a novel chemopreventive mechanism in human colon cancer cells and prostate epithelial cells, namely the inhibition of histone deacetylase (HDAC). IFeb 01, 2007

Sulforaphane protects against chemically-induced damage in bladder cells and tissues. Jan 01, 2003

Sulforaphane treatment resulted in a significant reduction in specific airway resistance and also increased small airway luminal area.Dec 31, 2014

Sulforaphane-containing broccoli sprout extracts induce a cytoprotective phase 2 response in mouse and human skin.Apr 01, 2007

Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles.Dec 31, 2013

Sulforaphane’s capacity to activate the Keap1–Nrf2 cytoprotective signaling pathway, and may protect against environmental and endogenous risk factors in autism spectrum disorders.Oct 27, 2014

Supplementation therapy of sulforaphane rich broccoli sprout extract may have the potential to improve cognitive deficits in patients with schizophrenia. Apr 29, 2015

Sulfur Rich Natural Substances

View the Evidence:
429 Abstracts with Sulfur Rich Natural Substances Research