Depression research focused on Cannabidiol

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225 Substances Researched for Depression

Name	AC	CK
Vitamin D	17	163
Saffron	13	119
Probiotics	21	101
Psilocybin	19	100
Curcumin	16	96
Magnesium	10	93
Ayahuasca	15	80
Omega-3 Fatty Acids	10	74
Fruit: All	5	60
Homeopathic Medicine: All	6	60
St. John's Wort	5	60
Vegetables: All	4	50
Rhodiola (Tibetan Ginseng)	5	42
DHA (Docosahexaenoic Acid)	3	40
EPA (Eicosapentaenoic Acid)	3	40
Lavender	4	40
Polyunsaturated Fatty Acids (PUFAs)	5	34
Fish	3	30
Kava Kava	2	30
Lavender: Essential Oil	2	30
SAMe (S-adenosylmethionine)	2	30
Tryptophan	3	30
Vitamin B-6	3	30
Ginsenosides	15	29
Flavonoids	7	28
St. Johns Wort	6	23
Coffee	3	22
Cannabidiol	12	21
Ginkgo biloba	2	21
Acetyl-l-carnitine	2	20
Bergamot	2	20
Chlorella (Algae)	2	20
Dehydroepiandrosterone (DHEA)	1	20
Docosahexaenoic acid (DHA)	1	20
Eicosapentaenoic acid (EPA)	1	20
Inositol	1	20
Riboflavin (Vitamin B-2)	2	20
Soy	2	20
Vitamin B-12	2	20
Yoghurt	2	20
Rosemary	4	16
Lion's Mane (Hericium Erinaceus)	4	15
Rose	4	15
Bifidobacterium Longum	3	14
Coenzyme Q10	3	14
Paeoniflorin	7	14
Palmitoylethanolamide	4	14
Fiber	2	13
Arginine	2	12
Ashwagandha	2	12
Dandelion	2	12
Bacopa	6	11
Cocoa	2	11
Frankincense	2	11
Melatonin	7	11
5-HTP (5-Hydroxytryptophan)	1	10
Berberine	5	10
Blue-Green Algae	1	10
Blueberry	1	10
Carotenoids	1	10
Chamomile	1	10
Crocin	1	10
Cysteine (see N-Acetylcysteine)	1	10
DHEA (Dehydroepiandrosterone)	1	10
Essential Fatty Acids	1	10
Eucalyptus	1	10
Goji	1	10
Hops	1	10
Lemon Balm	1	10
Lysergic Acid Diethylamide (LSD)	9	10
Maca	1	10
Marjoram	1	10
Motherwort	1	10
Niacin	1	10
Nuts	1	10
Piperidines	1	10
Psychedelics:All	6	10
Selenium	1	10
Vitamin B-3 (Niacin)	1	10
Vitamin B-5 (Pantothenic Acid)	1	10
Vitamin E	1	10
Walnut	1	10
Zinc	1	10
Hesperidin	4	8
Perillaldehyde	4	8
Piperine	4	8
Resveratrol	5	8
Banana	3	6
Ferulic acid	3	6
Gastrodin	3	6
Magnolol	3	6
Silymarin	3	6
Vitamin C	3	6
Chrysin	3	5
Fenugreek	3	5
Green Tea	3	5
Polyphenols	4	5
Valerian	3	5
Anise	2	4
Asparagus	2	4
Astaxanthin	2	4
Chlorogenic Acid	2	4
Citrus naringin	2	4
Coconut Husk/Fiber	2	4
Gardenia	2	4
Genipin	2	4
Lactobacillus helveticus	2	4
Luteolin	2	4
Naringenin	2	4
Onion	2	4
Salvia divinorum	3	4
Silibinin	2	4
Sulforaphane	2	4
Bael	2	3
Cannabinoids	2	3
Cannabis	2	3
Corn Silk	2	3
Huperzine	2	3
Panax Notoginseng	2	3
Passion Flower	2	3
Perilla	2	3
Thymoquinone	2	3
Allicin	1	2
Angelica	1	2
Apigenin	1	2
Arctigenin	1	2
Asiatic Acid	1	2
Bai Zhu	1	2
Bamboo	1	2
Banana Stem	1	2
Basil	1	2
Beta-Caryophyllene	1	2
Bifidobacterium	1	2
Bifidobacterium Infantis	1	2
Bitter Orange	1	2
Black Pepper	1	2
Broccoli Sprouts	1	2
Catuaba	1	2
Chokeberry	1	2
Coconut Water	1	2
Curry Leaves	1	2
D-Limonene	1	2
Delta-tetrahydrocannabinol (THC)	1	2
Dill	1	2
Ellagic Acid	1	2
Feijoa	1	2
Feverfew	1	2
Fisetin	1	2
Fish Oil	1	2
Flaxseed	1	2
Fucoxanthin	1	2
Gallic Acid	1	2
Garcinia Mangostana	1	2
Genistein	1	2
Geraniol	1	2
Ginseng	1	2
Ginseng (Korean)	1	2
Gotu Kola	1	2
Hawthorn	1	2
Hibiscus	1	2
Honokiol	1	2
Hydrogen Water	1	2
Kratom	2	2
Krill	1	2
Lactobacillus kefiranofaciens	1	2
Lactobacillus paracasei	1	2
Lactobacillus rhamnosus	1	2
Lettuce	1	2
Lobelia	1	2
Lotus	1	2
Lutein	1	2
Magnolia	1	2
Mangiferin	1	2
Mango	1	2
Moringa oleifera	1	2
Mucuna pruriens (aka Velvet Beans)	1	2
Mulberry	1	2
Musk (Animal)	1	2
Myricetin	1	2
NAC (N-acetyl-L-cysteine)	1	2
Nettle	1	2
Noni	1	2
Nutmeg	1	2
Orange	1	2
Orange: Mandarin	1	2
P-Coumaric Acid	1	2
Panax Ginseng	1	2
Peony	1	2
Prebiotics	2	2
Propolis: Bee	1	2
Pterostilbene	1	2
Pycnogenol (Pine Bark)	1	2
Quercetin	1	2
Red Sage	1	2
Rutin	1	2
Safranal	1	2
Seaweed: Brown	1	2
Sesamol	1	2
Strawberry	1	2
Tarragon	1	2
Theaflavins	1	2
Theanine	1	2
Thistle	1	2
Tualang Honey	1	2
Vitamin E: alpha tocopherol	1	2
Vitamin K2	1	2
White Mulberry	1	2
ALA (Alpha-Linolenic Acid)	1	1
Amla Fruit	1	1
Anthocyanins	1	1
Cannabichromene	1	1
Cannabigerol	1	1
Catechin	1	1
Curcumin: Degradiation byproducts	1	1
Endocannabinoids	1	1
Folic Acid	1	1
Graviola	1	1
Hyperforin	1	1
Mistletoe	1	1
Nigella sativa (aka Black Seed)	1	1
Oak	1	1
S-Adenosylmethionine (SAMe)	1	1
Sea buckthorn	1	1
Soursop	1	1
Syrian rue	1	1

37 Problem Substances Researched for Depression

Name	AC	CK
Fluoxetine (trade name Prozac)	21	154
Antidepressants	8	65
Sugar Sweetened Beverages	3	40
Sertraline	6	36
Oral Contraceptives	4	33
Selective Serotonin Reuptake Inhibitors (SSRIs)	3	22
Chemotherapy	1	20
Eszopiclone	1	20
Hypnotic Drugs	1	20
Ramelteon	1	20
Statin Drugs	2	20
Zaleplon	1	20
Zolpidem (trade name Ambien)	1	20
Bisphenol A	3	13
Simvastatin	2	11
Analgesic: Non-opioid	1	10
Aspirin	1	10
Clozapine	1	10
Electronic Cigarettes	1	10
Energy Drinks	1	10
Fenofibrates	1	10
Fried Foods	1	10
Gliadin	1	10
Hydrocarbons	1	10
Nicotine	1	10
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	10
Phthalates	1	10
Tobacco: Smoking	1	10
Tricresyl phosphates (TCPs)	1	10
Glyphosate	2	4
Dexamethasone	2	3
Oseltamivir (trade name Tamiflu)	1	3
Paroxetine (trade names Seroxat, Paxil)	1	3
Antibiotics	1	2
Arsenic	1	2
Bisphenol F	1	2
Monosodium Glutamate (MSG)	1	2

44 Therapeutic Actions Researched for Depression

Name	AC	CK
Yoga	23	177
Exercise	13	123
Acupuncture	13	122
Meditation	13	95
Mindfullness Training	10	91
Integrative Medicine	7	90
Horticultural Therapy (Gardening)	6	70
Light Therapy	4	50
Aromatherapy Massage	5	41
Emotional Freedom Technique	5	41
Music	4	41
Massage/Therapeutic Touch	3	40
Pilates	3	40
Electroacupuncture	7	38
Tai Chi	5	32
Aromatherapy	4	31
Shinrin-yoku (taking in the atmosphere of the forest)	4	31
Therapeutic Breathing	3	30
Yogic Technique: Sudarshan kriya	5	23
Exercise: Green	3	21
Acupressure	2	20
Cognitive Behavioural Approaches	2	20
Dietary Modification: Mediterranean Diet	2	20
Exercise: Aerobic	2	20
Hydrotherapy	2	20
Placebo Effect	2	20
Thermal Therapy: Far-Infrared	2	20
Laughter/Humor	2	11
Qigong	2	11
Acupressure: Auricular	1	10
Behavioral Treatment	1	10
Color Therapy	1	10
Dancing	1	10
Homeopathic Treatment	1	10
Hormone Replacement Therapy	1	10
Hypnosis	1	10
Positive Mood	1	10
Prevent Pain	1	10
Reiki Therapy	1	10
Sauna Therapy	1	10
Sound Therapy	1	10
Sunlight exposure	1	10
Whole-Body Vibration	1	10
Guided Imagery	1	1

13 Problematic Actions Researched for Depression

Name	AC	CK
Chemotherapy	1	20
Angioplasty	2	12
Blue Light (400−495 nm)	2	12
Western Diet	2	12
Electromagnetic Fields	2	11
Mobile Phone Radiation	2	11
Air Travel	1	10
Nocebo Effect	1	10
X-ray Mammography	1	10
Vasectomy	1	3
Prenatal Stress	1	2
Stress	1	2
Wi-Fi Radiation	1	1

Focused Research Articles 12
Cumulative Knowledge Score 19
Overall Research Rating GOOD

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View the Evidence:
12 Abstracts with Depression
& Cannabidiol Research

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Antidepressant-like effect induced by cannabidiol is dependent on brain serotonin levels.Jun 05, 2018

Click here to read the entire abstract

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jun 6. Epub 2018 Jun 6. PMID: 29885468

Article Published Date : Jun 05, 2018

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

[+]

Cannabidiol could represent a novel fast antidepressant drug, via enhancing both serotonergic and glutamate cortical signalling.Dec 18, 2015

Click here to read the entire abstract

Pubmed Data : Neuropharmacology. 2015 Dec 19. Epub 2015 Dec 19. PMID: 26711860

Article Published Date : Dec 18, 2015

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

[+]

Cannabidiol regulates the expression of hypothalamus-pituitary-adrenal axis-related genes in response to acute restraint stress.Oct 15, 2018

Click here to read the entire abstract

Pubmed Data : J Psychopharmacol. 2018 Oct 16:269881118805495. Epub 2018 Oct 16. PMID: 30324842

Article Published Date : Oct 15, 2018

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Anxiety, Depression

Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents

[+]

CBD induces antidepressant-like effects comparable to those of imipramine. Dec 31, 2009

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Br J Pharmacol. 2010 Jan ;159(1):122-8. Epub 2009 Dec 4. PMID: 20002102

Article Published Date : Dec 31, 2009

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Natural Substances Versus Drugs

[+]

CBD may be beneficial for the treatment of clinical depression and other states with prominent anhedonia.Dec 31, 2015

Click here to read the entire abstract

Pubmed Data : Neuropsychobiology. 2016 ;73(2):123-9. Epub 2016 Mar 25. PMID: 27010632

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

[+]

Delta-tetrahydrocannabinol, cannabidiol, and cannabichromene exert antidepressant-like actions in animal models.May 31, 2010

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacol Biochem Behav. 2010 Jun ;95(4):434-42. Epub 2010 Mar 21. PMID: 20332000

Article Published Date : May 31, 2010

Study Type : Animal Study

Additional Links

Substances : Cannabidiol, Cannabinoids , Cannabis, Delta-tetrahydrocannabinol (THC)

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

[+]

Effects of cannabidiol in males and females in two different rat models of depression.Dec 16, 2018

Click here to read the entire abstract

Pubmed Data : Physiol Behav. 2018 Dec 17. Epub 2018 Dec 17. PMID: 30571957

Article Published Date : Dec 16, 2018

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

[+]

Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms.Apr 26, 2019

Click here to read the entire abstract

Pubmed Data : J Chem Neuroanat. 2019 Apr 27 ;98:104-116. Epub 2019 Apr 27. PMID: 31039391

Article Published Date : Apr 26, 2019

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Depression

Pharmacological Actions : Antidepressive Agents, Brain-derived neurotrophic factor modulator

[+]

Pharmacokinetics of oral and intravenous cannabidiol and its antidepressant-like effects in chronic mild stress model.May 29, 2019

Click here to read the entire abstract

Pubmed Data : Environ Toxicol Pharmacol. 2019 May 30 ;70:103202. Epub 2019 May 30. PMID: 31173966

Article Published Date : May 29, 2019

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Depression

Pharmacological Actions : Antidepressive Agents, Brain-derived neurotrophic factor modulator

[+]

Cannabis and the cannabinoids in addition to their potential applications in the treatment of a number of serious illnesses.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Prog Chem Org Nat Prod. 2017;103:1-36. PMID: 28120229

Article Published Date : Dec 31, 2016

Study Type : Review

Additional Links

Substances : Cannabichromene , Cannabidiol, Cannabigerol , Cannabinoids , Cannabis

Diseases : Alzheimer's Disease, Cancers: All, Depression, Glaucoma, HIV Infections, Multiple Sclerosis, Neuralgia

[+]

This reviews preclinical and clinical on the efficacy of CBD for the treatment of motivational disorders.Feb 23, 2016

Click here to read the entire abstract

Pubmed Data : Annu Rev Neurosci. 2016 Feb 24. Epub 2016 Feb 24. PMID: 27023732

Article Published Date : Feb 23, 2016

Study Type : Review

Additional Links

Substances : Cannabidiol

Diseases : Anxiety Disorders, Depression, Drug Abuse

[+]

This summarizes the therapeutic effects of CBD and their relevance to brain function, neuroprotection and neuropsychiatric disorders.Jan 31, 2016

Click here to read the entire abstract

Pubmed Data : Pharmacol Res. 2016 Feb 1. Epub 2016 Feb 1. PMID: 26845349

Article Published Date : Jan 31, 2016

Study Type : Review

Additional Links

Substances : Cannabidiol

Diseases : Anxiety Disorders, Brain Damage, Brain Ischemia, Depression, Neurodegenerative Diseases, Psychiatric Disorders

Pharmacological Actions : Neuroprotective Agents

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Kava is safe and effective in treating anxiety disorders and depression. L-tryptophan is as effective as imipramine in treating depression. Saffron may be of therapeutic benefit in the treatment of mild to moderate depression and has similar efficacy as the drug imipramine. St. John's Wort is as effective as Selective Serotoin Reuptake Inhibitors (SSRI) in the treatment of Depressive Disorder, with a greater safety rating.

Is Your Diet Making You Moody?

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View the Evidence: 12 Abstracts with Depression & Cannabidiol Research

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Antidepressant-like effect induced by cannabidiol is dependent on brain serotonin levels.Jun 05, 2018

Cannabidiol could represent a novel fast antidepressant drug, via enhancing both serotonergic and glutamate cortical signalling.Dec 18, 2015

Cannabidiol regulates the expression of hypothalamus-pituitary-adrenal axis-related genes in response to acute restraint stress.Oct 15, 2018

CBD induces antidepressant-like effects comparable to those of imipramine. Dec 31, 2009

CBD may be beneficial for the treatment of clinical depression and other states with prominent anhedonia.Dec 31, 2015

Delta-tetrahydrocannabinol, cannabidiol, and cannabichromene exert antidepressant-like actions in animal models.May 31, 2010

Effects of cannabidiol in males and females in two different rat models of depression.Dec 16, 2018

Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms.Apr 26, 2019

Pharmacokinetics of oral and intravenous cannabidiol and its antidepressant-like effects in chronic mild stress model.May 29, 2019

Cannabis and the cannabinoids in addition to their potential applications in the treatment of a number of serious illnesses.Dec 31, 2016

This reviews preclinical and clinical on the efficacy of CBD for the treatment of motivational disorders.Feb 23, 2016

This summarizes the therapeutic effects of CBD and their relevance to brain function, neuroprotection and neuropsychiatric disorders.Jan 31, 2016

Depression Related Articles

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Depression research focused on Cannabidiol

View the Evidence:
12 Abstracts with Depression
& Cannabidiol Research