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Light Therapy Is More Effective Than Prozac In Major Depression

Light Therapy Is More Effective Than Prozac In Major Depression

Originally published on DoctorMurray.com.

Feeling SAD? New data shows that light therapy is more effective than Prozac on patients with significant depression.

Introduction:

Bright light therapy has a proven track record of success in the treatment of seasonal affective disorder (SAD), commonly referred to as the winter blues. A new study from the University of British Columbia shows that this simple and safe therapy is effective for non-seasonal major depression. In fact, researchers showed light therapy was much more effective than fluoxetine (Prozac).

Background Data:

During the winter months, sufferers of SAD typically feel depressed; they generally slow down, oversleep, overeat, and crave carbohydrates. In the summer, these same people feel elated, active, and energetic. Although many variables may be responsible for SAD, the lack of exposure to full-spectrum natural light appears to be the most logical explanation. The antidepressive effects of full-spectrum light therapy have been demonstrated in well-monitored, controlled studies in SAD.

The typical protocol used in clinical studies involved using specialized light boxes providing full-spectrum fluorescent tubes vs. regular tubes. Patients were then instructed to sit three feet away from the light anywhere from 30 minutes a day, up to three hours total, in morning and evening.

The antidepressant effect of light therapy is thought to be due to restoring proper melatonin synthesis and secretion by the pineal gland leading to re-establishment of the proper circadian rhythm – the normal rhythm of hormone secretion that occurs each day.

New Data:

Led by noted SAD and light therapy expert Raymond Lam, M.D., the UBC researchers randomly assigned 122 patients with major depression to either light therapy alone for 30 minutes a day; a placebo device, which did not provide full-spectrum lighting; the combination of light therapy plus fluoxetine, 20 mg a day; or the placebo device plus a placebo. Approximately 30 patients were enrolled in each of the four treatment groups.

All of the patients had a score of 20 or higher on two different standard scales of depression (HDS and MADRS) when the study started indicating significant depression. Furthermore, the duration of the current major depressive disorder episode ranged from a low of 45 weeks to 90 weeks.

Light therapy consisted of 30 minutes a day of exposure to a full-spectrum fluorescent light box as soon as possible after awakening. At the end of the 8-week treatment interval, mean changes in the depression score from baseline (MADRS) were significantly greater among those who received bright light therapy alone, compared to fluoxetine alone. Most significant was that 43.8% of the patients getting the bright light therapy went into remission compared to only 19.4% of the subjects taking fluoxetine. Best results were seen with combination of bright light therapy and fluoxetine than for any of the other treatment groups with a 58.6% remission rate.

These results show quite clearly that light therapy possesses an antidepressant effect even in non-seasonal major depression.

Commentary:

Light boxes similar to those used in clinical trials are available online and generally cost between $69 and $199. An alternative is to get outdoors in sunlight for 30 minutes a day or replace standard light bulbs with full-spectrum light bulbs in areas of your home or office where you spend a considerable amount of time.

Here are some other recommendations for SAD since it is that time of year:

  • Melatonin supplementation alone has produced mixed results in clinical trials in SAD. Nonetheless, some people do seem to respond to 2-3 mg of melatonin at bedtime and for further support in resetting their biological clock. I recommend taking the special form of vitamin B12 (methylcobalamin) at a dosage of 3-5 mg the first thing in the morning.
  • Vitamin D3 is absolutely essential for proper brain chemistry and neurotransmitter action. To insure optimal vitamin D status during the winter months, most health experts, myself included, are advocating daily dosages of 2,000 to 5,000 IU, even in apparently healthy adults.
  • John's Wort extract (SJWE) has shown to be very effective in reducing depression scores in patients with SAD and can be used to enhance the effects of the bright light therapy instead of standard antidepressant drugs. Typical dosage is 900 to 1,800 mg daily. Because SJWE can increase the activity of a drug detoxifying enzyme in the liver, it has been found to decrease the plasma concentrations of a long list of drugs. As a general rule, if you are taking any prescription medication, including birth control pills, do not take St. John's wort without approval from your physician.

Reference:

Lam RW, Levitt AJ, Levitan RD, et al. Efficacy of Bright Light Treatment, Fluoxetine, and the Combination in Patients With Nonseasonal Major Depressive Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2015 Nov 18:1-9.

 

Dr. Michael Murray
12/15/15

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

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