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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Different effect of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF-α stimulated pro-inflammatory environment.

Abstract Source:

Mol Nutr Food Res. 2016 Jun 21. Epub 2016 Jun 21. PMID: 27324255

Abstract Author(s):

Cristian Del Bo, Martin Roursgaard, Marisa Porrini, Steffen Loft, Peter Møller, Patrizia Riso

Article Affiliation:

Cristian Del Bo

Abstract:

SCOPE: Monocyte adhesion to the vascular endothelium is a crucial step in the early stages of atherogenesis. This study aims to investigate the capacity of an anthocyanin (ACN) and phenolic acid (PA)-rich fraction (RF) of a wild blueberry, single ACNs (cyanidin, malvidin, delphinidin) and related metabolites (protocatechuic, syringic and gallic acid) to counteract monocytes (THP-1) adhesion to endothelial cells (HUVECs) in a tumor necrosisα (TNF-α) mediated pro-inflammatory environment.

METHODS AND RESULTS: HUVECs were incubated with different concentrations (from 0.01 to 10μg mL(-1) ) of the compounds for 24 h. Labelled monocytic THP-1 cells were added to HUVECs and their adhesion was induced by TNF-α (100 ng mL(-1) ). ACN-RF reduced THP-1 adhesion to HUVECs with a maximum effect at 10 μg mL(-1) (-33%). PA-RF counteracted THP-1 adhesion at 0.01, 0.1 and 1 μg mL(-1) (-45%, -48.7% and -27.6%, respectively), but not at maximum concentration. Supplementation with gallic acid reduced THP-1 adhesion to HUVECs with a maximum effect at 1 μg mL(-1) (-29.9%), while malvidin-3-glucoside and syringic acid increased the adhesion. No effect was observed for the other compounds.

CONCLUSION: These results suggest that ACNs/PA-RF may prevent atherogenesis while the effects of the single ACNs and metabolites are controversial and merit further exploration. This article is protected by copyright. All rights reserved.

Study Type : In Vitro Study

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Depression: 21st Century Solutions + The Dark Side of Wheat

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