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Abstract Title:

Demethoxycurcumin and its semisynthetic analogues as antitubercular agents.

Abstract Source:

Planta Med. 2008 Dec;74(15):1828-31. Epub 2008 Nov 7. PMID: 18991209

Abstract Author(s):

Dinesh Kumar Agrawal, Dharmendra Saikia, Richa Tiwari, Shweta Ojha, Karuna Shanker, Jonnala Kotesh Kumar, Anil Kumar Gupta, Sudeep Tandon, Arvind Singh Negi, Suman Preet Khanuja

Abstract:

Demethoxycurcumin, isolated from the rhizomes of Curcuma longa, was found to possess antitubercular activity against Mycobacterium tuberculosis H (37)Rv strain at 200 microg/mL. Derivatisation of this active principle yielded a potent agent 6, exhibiting considerable activity with a minimum inhibitory concentration (MIC) value of 7.8 microg/mL. H (37)Rv:Mycobacterium tuberculosis H (37)Rv strain MIC:minimum inhibitory concentration.

Study Type : In Vitro Study

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Sayer Ji
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