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Abstract Title:

Temozolomide-Mediated Apoptotic Death Is Improved by Thymoquinone in U87MG Cell Line.

Abstract Source:

Cancer Invest. 2017 Apr 21 ;35(4):225-236. Epub 2017 Mar 29. PMID: 28355088

Abstract Author(s):

Mozafar Khazaei, Mona Pazhouhi

Article Affiliation:

Mozafar Khazaei

Abstract:

Apoptosis induction of cancer cells can be an appropriate strategy by which chemotherapeutic agents kill tumor cells. The aim of the present study was to investigate the effect of temozolomide and thymoquinone combination on apoptotic pathway of human glioblastoma multiforme cell line (U87MG). U87MG cells were cultured, treated with temozolomide and thymoquinone, and cell proliferation was measured. Apoptosis cell death and its possible mechanism were investigated by various methods. Combination of temozolomide and thymoquinone had a synergistic effect on cells viability. Thymoquinone intensified the temozolomide-induced apoptosis. Combination of temozolomide and thymoquinone can be a good strategy for treatment of glioblastoma.

Study Type : Human In Vitro

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Sayer Ji
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