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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Anti-gastritis and wound healing effects of Momordicae Semen extract and its active component.

Abstract Source:

Immunopharmacol Immunotoxicol. 2013 Feb ;35(1):126-32. Epub 2012 Aug 14. PMID: 22889079

Abstract Author(s):

Kiwon Jung, Young-Won Chin, Yoon Hee Chung, Yang Hae Park, Hunseung Yoo, Dong Sun Min, Bongyong Lee, Jinwoong Kim

Article Affiliation:

Kiwon Jung

Abstract:

Momordicae Semen, Momordica cochinchinensis Springer (Cucurbitaceae), has long been known to effectively relieve boils, rheumatic pain, and hemorrhoids. In this study, we investigated whether Momordicae Semen extract (MSE) has anti-gastritis effects in various rodent models and also explored possible mechanisms for the gastroprotective effects of MSE. MSE provided remarkable protective effects, comparable to those of rebamipide, in ethanol- and diclofenac-induced acute gastritis. In addition, it has demonstrated protective effect in a Helicobacter pylori-insulted chronic gastritis model. MSE also showed wound healing effect on cutaneous injury of mice and stimulated calcitonin gene-related peptide and somatostatin receptors, which may be related to its anti-gastritis effects. In a single oral dose toxicity study, the approximate lethal dose of MSE was determined at>2000 mg/kg/day. The NOAEL was set to be 2000 mg/kg/day from the repeated oral dose toxicity study. Moreover, momordica saponin I, a major ingredient of MSE, treatment decreased gastric mucosa damage indices in the ethanol- and diclofenac-induced acute gastritis models. The results suggest that MSE could be a promising gastroprotective herbal medicine and momordica saponin I might be used as an active marker compound for MSE.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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