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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Olive oil polyphenols enhance high-density lipoprotein function in humans: a randomized controlled trial.

Abstract Source:

Arterioscler Thromb Vasc Biol. 2014 Sep ;34(9):2115-9. Epub 2014 Jul 24. PMID: 25060792

Abstract Author(s):

Álvaro Hernáez, Sara Fernández-Castillejo, Marta Farràs, Úrsula Catalán, Isaac Subirana, Rosa Montes, Rosa Solà, Daniel Muñoz-Aguayo, Anna Gelabert-Gorgues, Óscar Díaz-Gil, Kristiina Nyyssönen, Hans-Joachim F Zunft, Rafael de la Torre, Sandra Martín-Peláez, Anna Pedret, Alan T Remaley, María-Isabel Covas, Montserrat Fitó

Article Affiliation:

Álvaro Hernáez

Abstract:

OBJECTIVE: Olive oil polyphenols have shown beneficial properties against cardiovascular risk factors. Their consumption has been associated with higher cholesterol content in high-density lipoproteins (HDL). However, data on polyphenol effects on HDL quality are scarce. We, therefore, assessed whether polyphenol-rich olive oil consumption could enhance the HDL main function, its cholesterol efflux capacity, and some of its quality-related properties, such HDL polyphenol content, size, and composition.

APPROACH AND RESULTS: A randomized, crossover, controlled trial with 47 healthy European male volunteers was performed. Participants ingested 25 mL/d of polyphenol-poor (2.7 mg/kg) or polyphenol-rich (366 mg/kg) raw olive oil in 3-week intervention periods, preceded by 2-week washout periods. HDL cholesterol efflux capacity significantly improved after polyphenol-rich intervention versus the polyphenol-poor one (+3.05% and -2.34%, respectively; P=0.042). Incorporation of olive oil polyphenol biological metabolites to HDL, as well as large HDL (HDL2) levels, was higher after the polyphenol-rich olive oil intervention, compared with the polyphenol-poor one. Small HDL (HDL3) levels decreased, the HDL core became triglyceride-poor, and HDL fluidity increased after the polyphenol-rich intervention.

CONCLUSIONS: Olive oil polyphenols promote the main HDL antiatherogenic function, its cholesterol efflux capacity. These polyphenols increased HDL size, promoted a greater HDL stability reflected as a triglyceride-poor core, and enhanced the HDL oxidative status, through an increase in the olive oil polyphenol metabolites content in the lipoprotein. Our results provide for the first time a first-level evidence of an enhancement in HDL function by polyphenol-rich olive oil.

Study Type : Human Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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