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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Anti-nociceptive effects of Carpolobia lutea G. Don (Polygalaceae) leaf fractions in animal models.

Abstract Source:

Inflammopharmacology. 2011 Aug ;19(4):215-25. Epub 2011 Feb 24. PMID: 21347744

Abstract Author(s):

Lucky Lebgosi Nwidu, Paul Alozie Nwafor, Viviane Cândida da Silva, Clenilson Martins Rodrigues, Lourdes Campaner dos Santos, Wagner Vilegas, Ricardo Luiz Nunes-de-Souza

Article Affiliation:

Lucky Lebgosi Nwidu

Abstract:

Leaves from Carpolobia lutea (Polygalaceae) were screened to establish the antiulcer ethnomedicinal claim and to quantitatively isolate, elucidate the active compounds by semi-preparative HPLC. The anti-nociceptive effects of Carpolobia lutea (CL) G. Don (Polygalaceae) organic leaf extracts were tested in experimental models in mice. The anti-nociceptive mechanism was determined using tail-flick test, acetic acid-induced abdominal constrictions, formalin-induced hind paw licking and the hot plate test. The fractions (ethanol, ethyl acetate, chloroform, n-hexane) and crude ethyl acetate extract of CL (770 mg/kg, i.p.) produced significant inhibitions of both phases of the formalin-induced pain in mice, a reduction in acetic acid-induced writhing as well as and an elevation of the pain threshold in the hot plate test in mice. The inhibitions were greater to those produced by indomethacin (5 mg/kg,i.p.). Ethyl acetate fraction revealed cinnamic and coumaric acids derivatives, which are described for the first time in literature. These cinnamalglucosides polyphenols characterised from CL may in part account for the pharmacological activities. These findings confirm its ethnomedical use in anti-inflammatory pain and in pains from gastric ulcer-associated symptoms.

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Depression: 21st Century Solutions + The Dark Side of Wheat

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