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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Anti-inflammatory effect of fucoxanthin on dextran sulfate sodium-induced colitis in mice.

Abstract Source:

Nat Prod Res. 2018 Nov 29:1-5. Epub 2018 Nov 29. PMID: 30488724

Abstract Author(s):

Yuan-Ping Yang, Qiao-Yun Tong, Shi-Hua Zheng, Ming-Dong Zhou, You-Meng Zeng, Ting-Ting Zhou

Article Affiliation:

Yuan-Ping Yang

Abstract:

The anti-inflammatory activities of fucoxanthin, a marine carotenoid derived from the macroalgae and microalgae, have been demonstrated in the previous studies. However, the effect of fucoxanthin on ulcerative colitis (UC), an inflammatory bowel disease, was still unclear. In this study, we evaluated the in vivo anti-inflammatory effect of fucoxanthin on dextran sulfate sodium(DSS)-induced colitis in mice. Fucoxanthin at the doses of 50 and 100 mg/kg/day significantly protected against DSS-induced gradual loss of body weight, exhibited inhibitory effects on the DSS-induced increase of disease activity index and colon shortening. Moreover, fucoxanthin treatment resulted in a marked amelioration of the histological damage in the colon, and reduced the colonic PGElevels in colitic mice. In addition, the DSS-induced overexpressions of inflammation-related molecules including COX-2 and NF-κB were significantly decreased in fucoxanthin-treated mice. These finding suggested that the use of fucoxanthin provides a new and attractive alternative to control UC.

Study Type : Animal Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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