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Article Publish Status: FREE
Abstract Title:

Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury.

Abstract Source:

Exp Ther Med. 2016 Oct ;12(4):2741-2746. Epub 2016 Sep 6. PMID: 27698779

Abstract Author(s):

Yan-Mei Xu, Guo-Hua Ding, Jie Huang, Yan Xiong

Article Affiliation:

Yan-Mei Xu

Abstract:

Tanshinone IIA is a chemical compound extracted from the root of traditional Chinese herbBunge. Tanshinone IIA has been suggested to possess anti-inflammatory activity and antioxidizing capability. Recently, accumulating results have indicated the antitumor activity of tanshinone IIA; thus, it has attracted increasing attention. In addition, tanshinone IIA has been indicated to attenuate ischemia/reperfusion induced renal injury (I/RIRI); however, little is known regarding the underlying mechanisms involved in this process. In the present study an I/RIRI rat model was used to analyze the effects of tanshinone IIA on myeloperoxidase (MPO), TNF-α and IL-6 activities using ELISA kits. Furthermore, macrophage migration inhibitory factor (MIF), cleaved caspase-3, B-cell lymphoma 2 (Bcl-2) and p38 mitogen-activated protein kinase (MAPK) protein expression levels were evaluated using western blot analysis. The results indicated that tanshinoneIIA protected renal function in I/RIRI rats. ELISA demonstrated that tanshinone IIA significantly reduced MIF, TNF-α and IL-6 activities in I/RIRI rats. Western blot analysis showed that tanshinone IIA significantly suppressed MIF, cleaved caspase-3 and p38 MAPK protein expression levels in I/RIRIrats. The present results suggest that tanshinone IIA pretreatment attenuates I/RIRI via the downregulation of MPO expression, inflammation, MIF, cleaved caspase-3 and p38 MAPK.

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