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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Perioperative synbiotic treatment to prevent infectious complications in patients after elective living donor liver transplantation: a prospective randomized study.

Abstract Source:

Am J Surg. 2010 Jul 7. Epub 2010 Jul 7. PMID: 20619394

Abstract Author(s):

Susumu Eguchi, Mitsuhisa Takatsuki, Masaaki Hidaka, Akihiko Soyama, Tatsuki Ichikawa, Takashi Kanematsu

Article Affiliation:

Department of Surgery, Nagasaki University, Graduate School of Biomedical Sciences, Nagasaki, Japan.

Abstract:

BACKGROUND: Although the effect of synbiotic therapy using prebiotics and probiotics has been reported in hepatobiliary surgery, there are no reports of the effect on elective living-donor liver transplantation (LDLT). METHODS: Fifty adult patients undergoing LDLT between September 2005 and June 2009 were randomized into a group receiving 2 days of preoperative and 2 weeks of postoperative synbiotic therapy (Bifidobacterium breve, Lactobacillus casei, and galactooligosaccharides [the BLO group]) and a group without synbiotic therapy (the control group). Postoperative infectious complications were recorded as well as fecal microflora before and after LDLT in each group. RESULTS: Only 1 systemic infection occurred in the BLO group (4%), whereas the control group showed 6 infectious complications (24%), with 3 cases of sepsis and 3 urinary tract infections with Enterococcus spp (P = .033 vs BLO group). No other type of complication showed any difference between the groups. CONCLUSIONS: Infectious complications after elective LDLT significantly decreased with the perioperative administration of synbiotic therapy.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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