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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

A Breathing-Based Meditation Intervention for Patients With Major Depressive Disorder Following Inadequate Response to Antidepressants: A Randomized Pilot Study.

Abstract Source:

J Clin Psychiatry. 2016 Nov 22. Epub 2016 Nov 22. PMID: 27898207

Abstract Author(s):

Anup Sharma, Marna S Barrett, Andrew J Cucchiara, Nalaka S Gooneratne, Michael E Thase

Article Affiliation:

Anup Sharma

Abstract:

OBJECTIVE: To evaluate feasibility, efficacy, and tolerability of Sudarshan Kriya yoga (SKY) as an adjunctive intervention in patients with major depressive disorder (MDD) with inadequate response to antidepressant treatment.

METHODS: Patients with MDD (defined by DSM-IV-TR) who were depressed despite≥ 8 weeks of antidepressant treatment were randomized to SKY or a waitlist control (delayed yoga) arm for 8 weeks. The primary efficacy end point was change in 17-item Hamilton Depression Rating Scale (HDRS-17) total score from baseline to 2 months. The key secondary efficacy end points were change in Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) total scores. Analyses of the intent-to-treat (ITT) and completer sample were performed. The study was conducted at the University of Pennsylvania between October 2014 and December 2015.

RESULTS: In the ITT sample (n = 25), the SKY arm (n = 13) showed a greater improvement in HDRS-17 total score compared to waitlist control (n = 12) (-9.77 vs 0.50, P = .0032). SKY also showed greater reduction in BDI total score versus waitlist control (-17.23 vs -1.75, P = .0101). Mean changes in BAI total score from baseline were significantly greater for SKY than waitlist (ITT mean difference: -5.19; 95% CI, -0.93 to -9.34; P = .0097; completer mean difference: -6.23; 95% CI, -1.39 to -11.07; P = .0005). No adverse events were reported.

CONCLUSIONS: Results of this randomized, waitlist-controlled pilot study suggest the feasibility and promise of an adjunctive SKY-based intervention for patients with MDD who have not responded to antidepressants.

TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT02616549.

Study Type : Human Study
Additional Links
Therapeutic Actions : Yoga : CK(1290) : AC(120)

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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