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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Diosgenin inhibited the expression of TAZ in hepatocellular carcinoma.

Abstract Source:

Biochem Biophys Res Commun. 2018 09 10 ;503(3):1181-1185. Epub 2018 Jul 11. PMID: 30005871

Abstract Author(s):

Zhize Chen, Jingjing Xu, Yang Wu, Shaoqing Lei, Huimin Liu, Qingtao Meng, Zhongyuan Xia

Article Affiliation:

Zhize Chen

Abstract:

Emerging evidence has supported that TAZ (transcriptional co-activator with PDZ binding motif), one transcription co-activator in Hippo signaling pathway, plays an oncogenic role in liver carcinogenesis. Targeting TAZ could be a potential therapeutic approach for liver cancer patients. In the current study, we aim to determine whether diosgenin could be an inhibitor of TAZ in liver cancer cells. We found that diosgenin inhibited the expression of TAZ in liver cancer cells. Moreover, we found that diosgenin inhibited cell growth, induced apoptosis, suppressed cell migration and invasion in part via inhibition of TAZ in liver cancer cells. Our study provides the evidence to support that diosgenin could be a potential agent for treating human liver cancer.

Study Type : In Vitro Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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