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Abstract Title:

Antrodia camphorata inhibits metastasis and epithelial-to-mesenchymal transition via the modulation of claudin-1 and Wnt/β-catenin signaling pathways in human colon cancer cells.

Abstract Source:

J Ethnopharmacol. 2017 Aug 17 ;208:72-83. Epub 2017 Jul 5. PMID: 28688953

Abstract Author(s):

You-Cheng Hseu, Yu-Hsien Chao, Kai-Yuan Lin, Tzong-Der Way, Hui-Yi Lin, Varadharajan Thiyagarajan, Hsin-Ling Yang

Article Affiliation:

You-Cheng Hseu

Abstract:

ETHNOPHARMACOLOGICAL RELEVANCE: Antrodia camphorata (AC) is a well known traditional Chinese medicinal mushroom in Taiwan, has been used to treat various diseases including cancer.

MATERIALS AND METHODS: In this study, we investigated the anti-metastatic and anti-EMT properties of a fermented culture broth of AC in human colon SW480and metastatic SW620cancer cells in vitro.

RESULTS: AC down-regulates claudin-1 and inhibits the proliferation and colony-formation abilities of both SW620and SW480cells. In highly metastatic SW620cells, non-cytotoxic concentrations of AC significantly inhibited migration/invasion, accompanied by the down-regulation of MMP-2 and MMP-9 proteins. AC decreased nuclear translocation of Wnt/β-catenin through a GSK3β-dependent pathway. AC consistently inhibited EMT by up-regulating the epithelial and downregulating the mesenchymal marker proteins. In SW480cells, AC suppressed migration/invasion potentially through the inhibition of the PI3K/AKT/NFκB signaling pathways without altering the expression levels of β-catenin and GSK3β proteins.

CONCLUSION: Altogether, this study demonstrates the anti-metastatic and anti-EMT activities of AC, which may contribute to the development of a chemopreventive agent for colon cancer.

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