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Depression: 21st Century Solutions + The Dark Side of Wheat

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Article Publish Status: FREE
Abstract Title:

Preventive Effect of Cow's Milk Fermented with Lactobacillus paracasei CBA L74 on Common Infectious Diseases in Children: A Multicenter Randomized Controlled Trial.

Abstract Source:

Nutrients. 2017 Jun 27 ;9(7). Epub 2017 Jun 27. PMID: 28654019

Abstract Author(s):

Giovanni Corsello, Maurizio Carta, Roberto Marinello, Marina Picca, Giulio De Marco, Maria Micillo, Dante Ferrara, Patrizia Vigneri, Gaetano Cecere, Pasqualina Ferri, Paola Roggero, Giorgio Bedogni, Fabio Mosca, Lorella Paparo, Rita Nocerino, Roberto Berni Canani

Article Affiliation:

Giovanni Corsello

Abstract:

: Fermented foods have been proposed to prevent common infectious diseases (CIDs) in children attending day care or preschool.

OBJECTIVES: To investigate the efficacy of dietary supplementation with cow's skim milk fermented with the probioticCBA L74 in reducing CIDs in children attending day care or preschool.Multicenter, randomized, double-blind, placebo-controlled trial on healthy children (aged 12-48 months) consuming daily 7 grams of cow's skim milk fermented withCBA L74 (group A), or placebo (maltodextrins group B) attending day care or preschool during the winter season. The main outcome was the proportion of children who experienced≥1 episode of CID during a 3-month follow-up. Fecal biomarkers of innate (α- and β-defensins, cathelicidin) and acquired immunity (secretory IgA) were also monitored.A total of 126 children (71 males, 56%) with a mean (SD) age of 33 (9) months completed the study, 66 in group A and 60 in group B. At intention to treat analysis, the proportion of children presenting≥1 CID was 60% in group A vs. 83% in group B, corresponding to an absolute risk difference (ARD) of -23% (95% CI: -37% to -9%,<0.01). At per-protocol-analysis (PPA), the proportion of children presenting≥1 CID was 18% in group A vs. 40% in group B, corresponding to an absolute risk difference (ARD) of -22% (95% CI: -37% to -6%,<0.01). PPA showed that the proportion of children presenting≥1 acute gastroenteritis (AGE) was significantly lower in group A (18% vs. 40%,<0.05). The ARD for the occurrence of≥1 AGE was -22% (95% CI: -37% to -6%,<0.01) in group A. Similar findings were obtained at PPA regarding the proportion of children presenting≥1 upper respiratory tract infection (URTI), which was significantly lower in group A (51% vs. 74%,<0.05), corresponding to an ARD of -23% (95% CI: -40% to -7%,<0.01). Significant changes in innate and acquired immunity biomarkers were observed only in subjects in group A.Dietary supplementation with cow's skim milk fermented withCBA L74 is an efficient strategy in preventing CIDs in children.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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