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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Evaluation of silymarin as a promising radioprotector.

Abstract Source:

Z Naturforsch C. 2010 May-Jun;65(5-6):337-46. PMID: 20653235

Abstract Author(s):

Manish Adhikari, Rajesh Arora, Raman Chawla, Jyoti Sharma, Atlar Singh Dhaker, Damodar Gupta, Neha Dubey, Raj Kumar, Veselin Ivanov, Veselina Gadjeva, Renata Gevrenova, Rakesh Kumar Sharma

Article Affiliation:

Institute of Nuclear Medicine and Allied Sciences, Brig SK Mazumdar Marg, Delhi-110054, India.

Abstract:

Silymarin, a purified extract of seeds of Silybum marianum L. and well known for its hepatoprotective abilities, has been evaluated for inherent utility as a radioprotective agent. A fraction (INM-7035) was authenticated by characterizing the percentage composition of silybin A and B (39.9% and 57.4%). Free radical scavenging activities of INM-7035 against superoxide radicals (>68%), hydroxyl radicals (>33.75%), DPPH (67.2%), and ABTS (32.4%) were also evaluated. The fraction chelated (>30%) ferrous ions, thereby able to restrict amplification. INM-7035 exhibited>50% peroxyl radical scavenging activity in the lipid phase along with dose-dependent (R2 = 0.990) reducing power in the aqueous phase. Radiation-induced free radical flux can lead to disruption of biomolecules like membrane lipids. INM-7035 completely inhibited lipid peroxidative stress in case of membranes against supralethal radiation stress in the liposomal system. The ability of INM-7035 to modulate the levels of NF-kappaB, indicated its inherent potential as a radioprotective bioactive constituent.

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Depression: 21st Century Solutions + The Dark Side of Wheat

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