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Abstract Title:

Schizandrin reverses memory impairment in rats.

Abstract Source:

Phytother Res. 2008 Jan;22(1):49-52. PMID: 17705144

Abstract Author(s):

Nobuaki Egashira, Kouji Kurauchi, Katsunori Iwasaki, Kenichi Mishima, Kensuke Orito, Ryozo Oishi, Michihiro Fujiwara

Abstract:

The present study investigated the effect of schizandrin, a component of the fruit of Schizandra chinesis Baill (Fructus Schizandrae), on memory impairment in rats. Scopolamine (0.5 mg/kg, i.p.), a non-selective muscarinic receptor antagonist, markedly impaired spatial memory in an eight-arm radial maze. A higher dose of scopolamine (3 mg/kg, i.p.) also impaired the passive avoidance response. Schizandrin (1 and 10 mg/kg, p.o.) significantly reversed the scopolamine-induced impairment of spatial memory. Similarly, schizandrin (1 mg/kg, p.o.) significantly reversed the scopolamine-induced impairment of the passive avoidance response. Moreover, in mice, schizandrin (1 and 10 mg/kg, p.o.) enhanced tremors induced by oxotremorine, a muscarinic M(1) receptor agonist. Taken together these findings suggest that schizandrin reverses scopolamine-induced memory impairment, in part, by enhancing cholinergic function, and that schizandrin might be useful for treating memory deficits. Copyright (c) 2007 John Wiley & Sons, Ltd.

Study Type : Animal Study

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Sayer Ji
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