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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Safranal Inhibits HeLa Cell Viability by Perturbing the Reassembly Potential of Microtubules.

Abstract Source:

Phytother Res. 2017 Oct 11. Epub 2017 Oct 11. PMID: 29024138

Abstract Author(s):

Sanith Cheriyamundath, Sinjan Choudhary, Manu Lopus

Article Affiliation:

Sanith Cheriyamundath

Abstract:

Saffron, a spice from Crocus sativus, has been known for its health benefits and medicinal properties. Safranal is a component of saffron and is known for its antioxidant and anticancer properties. In this study, we elucidated a possible tubulin-targeted antiproliferative mechanism of action of safranal. In vitro, the compound perturbed secondary structure of tubulin without altering net microtubule polymer mass. It inhibited HeLa cell viability in a concentration-dependent manner, with minimal damage to cellular microtubules. However, it strongly inhibited recovery of microtubule network after cold-induced disassembly, indicating its ability to interfere with the nucleation potential of tubulin. Further, as the acetylation pattern of the safranal-treated microtubules revealed, unlike many tubulin-targeted agents, the compound did not appear to induce persistent stabilization of microtubules. Our data shows an unusual, tubulin-targeted antiproliferative mechanism of safranal. Copyright© 2017 John Wiley&Sons, Ltd.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685)

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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