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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Royal jelly mitigates cadmium-induced neuronal damage in mouse cortex.

Abstract Source:

Mol Biol Rep. 2018 Nov 9. Epub 2018 Nov 9. PMID: 30414103

Abstract Author(s):

Rafa S Almeer, Rami B Kassab, Gadah I AlBasher, Saud Alarifi, Saad Alkahtani, Daoud Ali, Ahmed E Abdel Moneim

Article Affiliation:

Rafa S Almeer

Abstract:

This study aimed to evaluate the potential neuroprotective effect of royal jelly (RJ) against Cd-induced neuronal damage. Twenty-eight adult mice were placed equally into four groups. The control group received intraperitoneal (IP) injections of normal saline; the cadmium chloride (CdCl) group was IP-injected 6.5 mg/kg (mg per kg of bodyweight) CdCl; the RJ group was gavaged 85 mg/kg RJ; and the RJ + CdClgroup was orally administered 85 mg/kg RJ 2 h before receiving IP-injections of 6.5 mg/kg CdCl. All groups were treated for seven consecutive days and the mice were decapitated 24 h after the final dose. Cd accumulation was recorded in the cortical homogenates, accompanied by elevated levels of lipid peroxidation, nitric oxide, tumor necrosis factor-α, interleukin-1β, and the pro-apoptotic mRNA Bax and caspase-3. Meanwhile, significantly decreased levels of detoxifying antioxidant enzymes including GSH-Px, GSH-R, SOD, and CAT, anti-apoptotic mRNA Bcl-2, and monoamines such as norepinephrine, dopamine, and serotonin were also observed, along with reduced gene expression of Nrf2-dependent antioxidants. Interestingly, in mice pretreated with RJ, the assessed parametersremained near normal levels. Our data provide evidence that RJ treatment has the potential to protect cortical neurons in Cd-intoxicated mice via its antioxidant, anti-inflammatory, anti-apoptotic, and neuromodulatory activity.

Study Type : Animal Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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