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Depression: 21st Century Solutions + The Dark Side of Wheat

Article Publish Status: FREE
Abstract Title:

The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities.

Abstract Source:

Trends Pharmacol Sci. 2009 Aug ;30(8):411-20. Epub 2009 Jul 14. PMID: 19608284

Abstract Author(s):

Tamás Bíró, Balázs I Tóth, György Haskó, Ralf Paus, Pál Pacher

Article Affiliation:

Tamás Bíró

Abstract:

The newly discovered endocannabinoid system (ECS; comprising the endogenous lipid mediators endocannabinoids present in virtually all tissues, their G-protein-coupled cannabinoid receptors, biosynthetic pathways and metabolizing enzymes) has been implicated in multiple regulatory functions both in health and disease. Recent studies have intriguingly suggested the existence of a functional ECS in the skin and implicated it in various biological processes (e.g. proliferation, growth, differentiation, apoptosis and cytokine, mediator or hormone production of various cell types of the skin and appendages, such as the hair follicle and sebaceous gland). It seems that the main physiological function of the cutaneous ECS is to constitutively control the proper and well-balanced proliferation, differentiation and survival, as well as immune competence and/or tolerance, of skin cells. The disruption of this delicate balance might facilitate the development of multiple pathological conditions and diseases of the skin (e.g. acne, seborrhea, allergic dermatitis, itch and pain, psoriasis, hair growth disorders, systemic sclerosis and cancer).

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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