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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Anti-inflammatory effect of resveratrol by inhibition of IL-8 production in LPS-induced THP-1 cells.

Abstract Source:

Am J Chin Med. 2009;37(6):1203-14. PMID: 19938227

Abstract Author(s):

You-Chang Oh, Ok-Hwa Kang, Jang-Gi Choi, Hee-Sung Chae, Young-Seob Lee, Obiang-Obounou Brice, Hyun Ju Jung, Seung-Heon Hong, Young-Mi Lee, Dong-Yeul Kwon

Abstract:

Resveratrol is a polyphenol compound and prominent anti-inflammatory agent found in plants, including the fruits of Morus alba. However, the therapeutic mechanisms of resveratrol remain largely unclear. To gain insight into the biological effects of resveratrol, we examined its influence on LPS-induced IL-8 production in the human monocytic cell line, THP-1. In inflammatory diseases, IL-8 plays a central role in the initiation and maintenance of inflammatory response. In the present study, IL-8 production was measured by ELISA and RT-PCR, while MAPK activation, IkappaBalpha degradation, nuclear factor (NF)-kappaB activation and cyclooxygenase (COX)-2 expression were determined by Western blot analysis. Resveratrol inhibited LPS-induced IL-8 production in a dose-dependent manner. Furthermore, resveratrol inhibited extracellular signal-regulated kinase (ERK) and p38 MAPK phosphorylation, IkappaBalpha degradation, NF-kappaB activation and cyclooxygenase (COX)-2 expression, which suggest that resveratrol inhibits IL-8 secretion by blocking MAPK phosphorylation and NF-kappaB activation. Taken together, these findings may help elucidate the mechanism by which resveratrol modulates THP-1 cell activation under inflammatory conditions.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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