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Article Publish Status: FREE
Abstract Title:

Resveratrol plays important role in protective mechanisms in renal disease--mini-review.

Abstract Source:

J Bras Nefrol. 2015 Jan-Mar;37(1):106-14. PMID: 25923757

Abstract Author(s):

Guilherme Albertoni, Nestor Schor

Article Affiliation:

Guilherme Albertoni

Abstract:

Resveratrol (RESV) is a polyphenolic compound found in various plants, including grapes, berries and peanuts, and its processed foods as red wine. RESV possesses a variety of bioactivities, including antioxidant, anti-inflammatory, cardioprotective, antidiabetic, anticancer, chemopreventive, neuroprotective, renal lipotoxicity preventative, and renal protective effects. Numerous studies have demonstrated that polyphenols promote cardiovascular health. Furthermore, RESV can ameliorate several types of renal injury in animal models, including diabetic nephropathy, hyperuricemic, drug-induced injury, aldosterone-induced injury, ischemia-reperfusion injury, sepsis-related injury, and endothelial dysfunction. In addition, RESV can prevent the increase in vasoconstrictors, such as angiotensin II (AII) and endothelin-1 (ET-1), as well as intracellular calcium, in mesangial cells. Together, these findings suggest a potential role for RESV as a supplemental therapy for the prevention of renal injury.

Study Type : Review

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Sayer Ji
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