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Abstract Title:

Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease.

Abstract Source:

Chem Pharm Bull (Tokyo). 1998 Oct;46(10):1607-12. PMID: 9810695

Abstract Author(s):

B S Min, N Nakamura, H Miyashiro, K W Bae, M Hattori

Article Affiliation:

Research Institute for Traditional Sino-Japanese Medicines, Toyama Medical and Pharmaceutical University, Japan.

Abstract:

Two new lanostane-type triterpenes, lucidumol A and ganoderic acid beta, were isolated from the spores of Ganoderma (G.) lucidum, together with a new natural one and seven that were known. The structures of the new triterpenes were determined as (24S)-24,25-dihydroxylanost-8-ene-3,7-dione and 3 beta,7 beta-dihydroxy-11,15-dioxolanosta-8,24(E)-dien-26-oic acid, respectively, by chemical and spectroscopic means. The quantitative analyses of 5 fruiting bodies, antlered form and spores of G. lucidum were performed by high performance liquid chromatography and demonstrated that ganoderic alcohol and acid contents were quite high in the spore. Of the compound isolated, ganoderic acid beta, (24S)-lanosta-7,9(11)-diene-3 beta,24,25-triol (called lucidumol B), ganodermanondiol, ganodermanontriol and ganolucidic acid A showed significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC50 values of 20-90 microM.

Study Type : In Vitro Study

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Depression: 21st Century Solutions + The Dark Side of Wheat

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