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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Protective Effects of Quercetin Against Cadmium Chloride-Induced Oxidative Injury in Goat Sperm and Zygotes.

Abstract Source:

Biol Trace Elem Res. 2018 Feb 4. Epub 2018 Feb 4. PMID: 29397540

Abstract Author(s):

Tingchao Mao, Chengquan Han, Biao Wei, Lu Zhao, Qing Zhang, Ruizhi Deng, Jun Liu, Yan Luo, Yong Zhang

Article Affiliation:

Tingchao Mao

Abstract:

Quercetin, a plant-derived flavonoid, is frequently used as an antioxidant for efficient anti-oxidative capacity. However, whether quercetin has protective effects on goat sperm and preimplantation embryos against Cd2+-induced oxidative injury is still unclear. So, we researched the influence of quercetin on goat sperm and zygotes respectively under the oxidative stress induced by Cd2+. In our study, quercetin decreased the malonaldehyde (MDA) and reactive oxygen species (ROS) levels caused by Cd2+ in goat sperm (p < 0.05), which facilitated sperm characteristics including motility, survival rates, membrane integrity, and mitochondria activity during storage in vitro and subsequent embryo development (p < 0.05). Moreover, in goat zygotes, quercetin decreased peroxidation products including ROS, MDA, and carbonyl through preserving or maintaining mitochondrial function, gene expression, and anti-oxidative products such as glutathione peroxidase, superoxide dismutase, and catalase, which amelioratedsubsequent embryo development and embryo quality (p < 0.05). Taken together, these results suggest that quercetin protects both goat sperm and preimplantation embryos from Cd2+-induced oxidative stress.

Study Type : In Vitro Study

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Depression: 21st Century Solutions + The Dark Side of Wheat

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