Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

500+ pages of Natural Medicine Alternatives and Information.

Abstract Title:

Puerarin inhibits acid-sensing ion channels and protects against neuron death induced by acidosis.

Abstract Source:

Planta Med. 2009 Nov 16. PMID: 19918715

Abstract Author(s):

Ling Gu, Yi Yang, Yiguo Sun, Xiaoxiang Zheng

Abstract:

Puerarin, the main isoflavone found in the root of the wild leguminous creeper PUERARIA LOBATA (Willd.) Ohwi, is known to protect the brain from ischemia-induced injuries. However, its effect on acidosis, a byproduct of brain ischemia and one factor promoting cell death, remains unknown. The purpose of this study was to investigate the effects of puerarin on acid-sensing ion channels (ASICs), which are reported to be activated by extracellular acidosis. Using the MTT assay and Hoechst/PI staining, we showed that puerarin could prevent hippocampal cell death during extracellular low pH. Data from whole-cell patch clamp recordings demonstrated that puerarin decreased the amplitude of ASIC currents and accelerated the desensitization of ASICs. Puerarin also reduced the amplitude of homomeric ASIC1a channels in CHO cells expressing pECFP-ASIC1a. Collectively, our study demonstrated that puerarin prevented hippocampal cells from acidosis-induced death via ASIC blockage, providing a mechanical insight into the neuroprotective effects of puerarin during brain ischemia. © Georg Thieme Verlag KG Stuttgart · New York.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.