Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

n/a
Article Publish Status: FREE
Abstract Title:

Protective effects of asiatic acid in a spontaneous type 2 diabetic mouse model.

Abstract Source:

Mol Med Rep. 2017 Aug ;16(2):1333-1339. Epub 2017 Jun 2. PMID: 28586016

Abstract Author(s):

Wen Sun, Guangyuan Xu, Xuan Guo, Guangbin Luo, Lili Wu, Yi Hou, Xiangyu Guo, Jingxin Zhou, Tunhai Xu, Lingling Qin, Yixin Fan, Li Han, Motlalepula Matsabisa, Xuesheng Ma, Tonghua Liu

Article Affiliation:

Wen Sun

Abstract:

Asiatic acid (AA) has been demonstrated to exhibit anti-diabetic activity. However, the mechanisms and underlying signaling pathways remain to be elucidated. The present study was performed to confirm the protective effect of AA and demonstrate its ability to regulate the phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (AKT)/glycogen synthase kinase‑3β (GSK‑3β) signaling pathway in db/db mice. Db/db mice fed on a high‑fat diet were used to model diabetes mellitus. Modeled mice were divided randomly into the model control, pioglitazone hydrochloride tablet (PH) and AA groups. Age‑matched C57 BL/6J mice served as normal controls. Lipid and glucose levels, and glycogen synthesis rates were assessed following treatment. Pathological changes were detected using hematoxylin and eosin staining. Expression of the PI3K/AKT/GSK‑3β signaling pathway at the mRNA level was measured using quantitative polymerase chain reaction analysis. The model control group revealed typical characteristics of obesity and diabetes, including high glucose and lipid levels, and decreased glycogen synthesis. Four weeks of treatment with AA or PH ameliorated these abnormalities. AA and PHtreatments mitigated the upregulation of PI3K, AKT, insulin receptor, and insulin receptor substrate‑1 mRNA expression in modeled mice. Furthermore, AA and PH treatments decreased GSK‑3β and glucose‑6‑phosphatase mRNA expression compared with the normal control group. The results of the present study confirmed that AA possesses anti‑diabetic activity in db/db mice. The PI3K/AKT/GSK‑3β signaling pathway may mediate this protective effect.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.