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Abstract Title:

Effect of Brazilian propolis on sneezing and nasal rubbing in experimental allergic rhinitis of mice.

Abstract Source:

Immunopharmacol Immunotoxicol. 2009;31(4):688-93. PMID: 19874242

Abstract Author(s):

Yoshifumi Shinmei, Haruna Yano, Yoto Kagawa, Kana Izawa, Masaaki Akagi, Toshio Inoue, Chiaki Kamei

Abstract:

We studied the effect of Brazilian propolis on sneezing and nasal rubbing in experimental allergic rhinitis of mice. A single administration of propolis caused no significant effect on both antigen-induced nasal rubbing and sneezing at a dose of 1000 mg/kg, but a significant inhibition was observed after repeated administration for 2 weeks at this dose. Propolis caused no significant inhibitory effect on the production of total IgE level after repeated administration of 1000 mg/kg. The drug also caused no significant inhibition of histamine-induced nasal rubbing and sneezing at a dose of 1000 mg/kg. On the other hand, propolis significantly inhibited histamine release from rat mast cells induced by antigen and compound 48/80 at a concentration of more than 10 microg/ml. These results clearly demonstrated that propolis may be effective in the relief of symptoms of allergic rhinitis through inhibition of histamine release.

Study Type : Animal Study

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Sayer Ji
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