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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Promising Anti-tumor properties of Bisdemethoxycurcumin: A Naturally Occurring Curcumin Analogue.

Abstract Source:

J Cell Physiol. 2017 Jan 11. Epub 2017 Jan 11. PMID: 28075008

Abstract Author(s):

Mahin Ramezani, Mahdi Hatamipour, Amirhosein Sahebkar

Article Affiliation:

Mahin Ramezani

Abstract:

Curcuminoids are turmeric-extracted phytochemicals with documented chemopreventive and anti-tumor activities against several types of malignancies. Curcuminoids can modulate several molecular pathways and cellular targets involved in different stages of tumor initiation, growth and metastasis. Bisdemethoxycurcumin (BDMC) is a minor constituent (approximately 3%) of curcuminoids that has been shown to be more stable than the other two main curcuminoids i.e. curcumin and demthoxycurcumin. Recent studies have revealed that BDMC has anti-tumor effects exerted through a multimechanistic mode of action involving inhibition of cell proliferation, invasion and migration, metastasis and tumour growth, and induction of apoptotic death in cancer cells. The present review discusses the findings on the anti-tumor effects of BDMC, underlying mechanisms and the relevance of finding for translational studies in human. This article is protected by copyright. All rights reserved.

Study Type : Review

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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