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Abstract Title:

Structure and antioxidative property of a polysaccharide from an ammonium oxalate extract of Phellinus linteus.

Abstract Source:

Int J Biol Macromol. 2016 Oct ;91:92-9. Epub 2016 May 17. PMID: 27212213

Abstract Author(s):

Jing-Kun Yan, Yao-Yao Wang, Zhen-Bin Wang, Hai-Le Ma, Juan-Juan Pei, Jian-Yong Wu

Article Affiliation:

Jing-Kun Yan

Abstract:

In this paper, the novel polysaccharide PL-A11 was purified from an ammonium oxalate extract of Phellinus linteus mycelia. Its physicochemical properties, structural characteristics, and antioxidant activities were investigated. Results showed that PL-A11 had a weight-average molecular weight (Mw) of 13.8kDa and was mainly composed of arabinose, xylose, mannose, and glucose in a molar ratio of 1.1:1.3:1.0:6.6. The backbone of PL-A11 was composed of (1→4)-α-d-glucopyranosyl, (1→2)-α-d-xylopyranosyl, and (1→3)-α-d-arabinofuranosyl residues, whereas the (1→6)-α-d-mannopyranosyl residues formed branches at the O-2 position with 1-linked-α-d-glucopyranosyl terminal residues. From the antioxidative activity tests in vivo, the administration of PL-A11 obviously enhanced the activity of antioxidant enzymes and significantly reduced the level of malondiadehyde (MDA) in the serum and liver of d-galactose-treated aging mice in a dose-dependent manner, as well as effectively stimulated the immune system of aging mice. These findings implied that PL-A11 could be developed as a potential antioxidant for applications in the functional food, pharmaceutical, cosmetic or nutraceutical industries.

Study Type : Animal Study

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