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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Piceatannol exhibits selective toxicity to multiple myeloma cells and influences the Wnt/ beta-catenin pathway.

Abstract Source:

Hematol Oncol. 2014 Dec ;32(4):197-204. Epub 2014 Jan 27. PMID: 24470348

Abstract Author(s):

Frederic Carsten Schmeel, Leonard Christopher Schmeel, Young Kim, Ingo G H Schmidt-Wolf

Article Affiliation:

Frederic Carsten Schmeel

Abstract:

Aberrant activation of Wnt/β-catenin signaling promotes development and progression of various malignant neoplasms. Recent studies observed that the Wnt pathway is constitutively active in myeloma cells and promotes an exaggerated proliferation. Thus, the Wnt signaling pathway might be an attractive therapeutic target for multiple myeloma. In this study, we identified piceatannol as an inhibitor of the Wnt/β-catenin pathway and as a potent inducer of apoptosis in myeloma cells. Interestingly, healthy cells remained mainly unaffected. These results reveal a significant selective induction of apoptosis by piceatannol and suggest a significant in vivo effect against multiple myeloma.

Study Type : In Vitro Study

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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