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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

HIV-1 inhibitory compounds from Calophyllum brasiliense leaves.

Abstract Source:

Biol Pharm Bull. 2004 Sep;27(9):1471-5. PMID: 15340243

Abstract Author(s):

Maira Huerta-Reyes, Maria Del Carmen Basualdo, Fumiko Abe, Manuel Jimenez-Estrada, Carmen Soler, Ricardo Reyes-Chilpa

Article Affiliation:

Department of Natural Products, Institute of Chemistry, National University of Mexico, Ciudad Universitaria, 04510, Mexico D. F., Mexico.

Abstract:

The hexane, acetone and methanol extracts of Calophyllum brasiliense leaves were fractionated following a three bioassay guide: high HIV-1 RT inhibition, low cytotoxicity on MT2 cells and high inhibition of HIV-1 IIIb/LAV replication. This led to the isolation of three anti HIV-1 dipyranocoumarins: calanolides A and B and soulattrolide. In contrast, other isolated compounds such as apetalic acid, isoapetalic acid, a structural isomer of isoapetalic acid, friedelin, canophyllol and amentoflavone were devoid of HIV-1 RT inhibitory activity. Calanolide C was also obtained as a natural product and showed moderate inhibitory properties.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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