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Depression: 21st Century Solutions + The Dark Side of Wheat

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Article Publish Status: FREE
Abstract Title:

Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson's Disease.

Abstract Source:

Evid Based Complement Alternat Med. 2017 ;2017:8429290. Epub 2017 Aug 1. PMID: 28835767

Abstract Author(s):

Luiz Eduardo Mateus Brandão, Diana Aline Morais Ferreira Nôga, Aline Lima Dierschnabel, Clarissa Loureiro das Chagas Campêlo, Ywlliane da Silva Rodrigues Meurer, Ramón Hypolito Lima, Rovena Clara Galvão Januário Engelberth, Jeferson Souza Cavalcante, Clésio Andrade Lima, Murilo Marchioro, Charles Dos Santos Estevam, José Ronaldo Santos, Regina Helena Silva, Alessandra Mussi Ribeiro

Article Affiliation:

Luiz Eduardo Mateus Brandão

Abstract:

Masters is a Brazilian native species of passionflower. This genus is known in the American continent folk medicine for its diuretic and analgesic properties. Nevertheless, few studies investigated possible biological effects ofextracts. Further, evidence of antioxidant actions encourages the investigation of possible neuroprotective effects in animal models of neurodegenerative diseases. This study investigates the effect of theethanolic extract (PAS) on mice submitted to a progressive model of Parkinson's disease (PD) induced by reserpine. Male (6-month-old) mice received reserpine (0.1 mg/kg, s.c.), every other day, for 40 days, with or without a concomitant treatment with daily injections of PAS (25 mg/kg, i.p.). Catalepsy, open field, oral movements, and plus-maze discriminative avoidance evaluations were performed across treatment, and immunohistochemistry for tyrosine hydroxylase was conducted at the end. The results showed that PAS treatment delayed the onset of motor impairments and prevented the occurrence of increased catalepsy behavior in the premotor phase. However, PAS administration did not modify reserpine-induced cognitive impairments. Moreover, PAS prevented the decrease in tyrosine hydroxylase immunostaining in the(SNpc) induced by reserpine. Taken together, our results suggested that PAS exerted a neuroprotective effect in a progressive model of PD.

Study Type : Animal Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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