Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

n/a
Abstract Title:

Aronia (Aronia melanocarpa) Polyphenols Modulate Microbial Community in Simulator of the Human Intestinal Microbial Ecosystem (SHIME) and Decrease Secretion of Pro-Inflammatory Markers in a Caco-2/endothelial Cell Co-Culture Model.

Abstract Source:

Mol Nutr Food Res. 2018 Sep 19:e1800607. Epub 2018 Sep 19. PMID: 30231187

Abstract Author(s):

Ting Wu, Charlotte Grootaert, Judit Pitart, Nevena Kardum Vidovic, Senem Kamiloglu, Sam Possemiers, Maria Glibetic, Guy Smagghe, Katleen Raes, Tom Van de Wiele, John Van Camp

Article Affiliation:

Ting Wu

Abstract:

SCOPE: To explore the mechanisms behind the health effects of Aronia (Aronia melanocarpa), the microbial community modulating and anti-inflammatory effects of Aronia polyphenols were investigated by combining SHIMEwith a co-culture of intestinal and endothelial cells.

RESULTS: Administration of Aronia juice (6.5g/L) to the SHIMEfor 2 weeks increased the abundance of Firmicutes to 92% in AC, 85% in TC and 82% in DC(p < 0.001), Proteobacteria(6.7% in AC, p < 0.001) and Akkermansia (14% in TC and 18% in DC, p < 0.001) and decreased the abundance of Bifidobacterium species, associated with a decrease of acetate and increase of propionate and butyrate, whereas no significant difference was observed upon placebo juice treatment. After addition of the digests to TNF-α challenged Caco-2/endothelial co-cultures, ICAM-1, IL-8 and MCP-1 levels were significantly downregulated. Interestingly, Aronia juice treated digests from each colon compartments resulted in a stronger decrease of the ICAM-1 secretion (up to 73%, p < 0.001) compared to their corresponding placebo treated digests, thereby pointing to a polyphenol-dependent effect.

CONCLUSIONS: Aronia polyphenols modulate intestinal microbial composition, induce beneficial SCFA production and prevent inflammatory stress in endothelial cells. This opens perspectives for the use of Aronia polyphenols as prebiotics in the context of intestinal and cardiovascular health. This article is protected by copyright. All rights reserved.

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.