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Abstract Title:

Olea europaea leaf extract and bevacizumab synergistically exhibit beneficial efficacy upon human glioblastoma cancer stem cells through reducing angiogenesis and invasion in vitro.

Abstract Source:

Biomed Pharmacother. 2017 Apr 15 ;90:713-723. Epub 2017 Apr 15. PMID: 28419967

Abstract Author(s):

Gulcin Tezcan, Mevlut Ozgur Taskapilioglu, Berrin Tunca, Ahmet Bekar, Hilal Demirci, Hasan Kocaeli, Secil Ak Aksoy, Unal Egeli, Gulsah Cecener, Sahsine Tolunay

Article Affiliation:

Gulcin Tezcan

Abstract:

Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p=0.0001, p<0.001, p=0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM.

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Sayer Ji
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