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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Nobiletin reduces LPL-mediated lipid accumulation and pro-inflammatory cytokine secretion through upregulation of miR-590 expression.

Abstract Source:

Biochem Biophys Res Commun. 2019 Jan 1 ;508(1):97-101. Epub 2018 Nov 22. PMID: 30471854

Abstract Author(s):

Ping-Ping He, Qian-Qian Shen, Min Wen, Jie-Qiong Zou, Yan Wang, Jiao-Xing Yang, Li-Zhi Hu, Xi-Long Zheng, Ye-Shi Chen, Hua Su, Juan Liu, Xin-Ping Ouyang, Chao-Ke Tang

Article Affiliation:

Ping-Ping He

Abstract:

Nobiletin has protective effects on cardiovascular diseases, but the mechanism is not clear. In this study, we examined whether nobiletin affects the expression of miR-590/LPL and its relative effects on lipid accumulation and pro-inflammatory cytokine secretion in human THP-1 macrophages. RT-qPCR analysis showed that nobiletin increased the expression of miR-590. Western blot analysis showed that nobiletin-suppressed LPL expression was enhanced by miR-590 mimic and abrogated by miR-590 inhibitor. Oil Red O staining and high-performance liquid chromatography assays showed that nobiletin attenuated lipid accumulation in macrophages. Treatment with nobiletin and miR-590 mimic decreased cellular lipid accumulation, whereas treatment with miR-590 inhibitor increased cellular lipid accumulation. ELISA illustrated that nobiletin alleviated pro-inflammatory cytokine secretion in macrophages as measured by, which was reduced by miR-590 mimic and increased by miR-590 inhibitor. In conclusion, nobiletin may alleviate lipid accumulation and secretion of pro-inflammatory cytokines by enhancing the inhibitory effect of miR-590 on LPL expression, suggesting a promising strategy for potential drug development for atherosclerosis.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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