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Article Publish Status: FREE
Abstract Title:

A glance at black cumin () and its active constituent, thymoquinone, in ischemia: a review.

Abstract Source:

Iran J Basic Med Sci. 2018 Dec ;21(12):1200-1209. PMID: 30627362

Abstract Author(s):

Zahra Oskouei, Maryam Akaberi, Hossein Hosseinzadeh

Article Affiliation:

Zahra Oskouei

Abstract:

Objectives: Black cumin () belonging to Ranunculaceae family has a long history of medicinal use in various folk and traditional systems of medicine, including Iranian traditional medicine (ITM). These valuable medicinal seeds have been used traditionally against a variety of diseases such as dyspepsia, diabetes, headache, influenza and asthma. In addition, several scientific investigations have reported the therapeutic properties ofand thymoquinone (TQ), one of the most important constituent of black cumin, for treatment of a large number of diseases, including ischemia. As there is no comprehensive review study about the anti-ischemic activity of black cumin and its mechanism of action, in the current study, we aimed to review the anti-ischemic activities ofand TQ in different organ-related disorders.

Materials and Methods: We searched the wordsor black cumin and ischemia in the combination of related organs through available databases including Scopus, Web of Science, and Google Scholar.

Results: Several studies were found reporting the anti-ischemic activity of black cumin and its active constituent on different organs including brain, kidneys, heart, and liver. Black cumin exert its beneficial effects as an antioxidant, anti-inflammatory, anti-apoptosis, and anti-necrosis agent through inhibition of growth factors, biochemical and oxidative stress markers and regulating gene expression.

Conclusion: Thus,could be a potential candidate for treatment of ischemia related disorders in key organs such as brain, liver, digestive system, kidney, and heart. To figure out the exact mechanism of action, further investigations are proposed in this regard.

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