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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Modulation of gut microbiota from obese individuals by in vitro fermentation of citrus pectin in combination with Bifidobacterium longum BB-46.

Abstract Source:

Appl Microbiol Biotechnol. 2018 Oct ;102(20):8827-8840. Epub 2018 Aug 18. PMID: 30121748

Abstract Author(s):

Fernanda Bianchi, Nadja Larsen, Thatiana de Mello Tieghi, Maria Angela Tallarico Adorno, Witold Kot, Susana Marta Isay Saad, Lene Jespersen, Katia Sivieri

Article Affiliation:

Fernanda Bianchi

Abstract:

This study aimed to evaluate the effects of three treatments, i.e., Bifidobacterium longum BB-46 (T1), B. longum BB-46 combined with the pectin (T2), and harsh extracted pectin from lemon (T3) on obesity-related microbiota using the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®). The effects of the treatments were assessed by the analysis of the intestinal microbial composition (using 16S rRNA gene amplicon sequencing) and the levels of short-chain fatty acids (SCFAs) and ammonium ions (NH). Treatments T2 and T3 stimulated members of the Ruminococcaceae and Succinivibrionaceae families, which were positively correlated with an increase in butyric and acetic acids. Proteolytic bacteria were reduced by the two treatments, concurrently with a decrease in NH. Treatment T1 stimulated the production of butyric acid in the simulated transverse and descending colon, reduction of NHas well as the growth of genera Lactobacillus, Megamonas, and members of Lachnospiracea. The results indicate that both B. longum BB-46 and pectin can modulate the obesity-related microbiota; however, when the pectin is combined with B. longum BB-46, the predominant effect of the pectin can be observed. This study showed that the citric pectin is able to stimulate butyrate-producing bacteria as well as genera related with anti-inflammatory effects. However, prospective clinical studies are necessary to evaluate the anti/pro-obesogenic and inflammatory effects of this pectin for future prevention of obesity.

Study Type : In Vitro Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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