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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Neuroprotective Mechanisms of Melatonin in Hemorrhagic Stroke.

Abstract Source:

Cell Mol Neurobiol. 2017 Jan 28. Epub 2017 Jan 28. PMID: 28132129

Abstract Author(s):

Hai-Jian Wu, Cheng Wu, Huan-Jiang Niu, Kun Wang, Lian-Jie Mo, An-Wen Shao, Brandon J Dixon, Jian-Min Zhang, Shu-Xu Yang, Yi-Rong Wang

Article Affiliation:

Hai-Jian Wu

Abstract:

Hemorrhagic stroke which consists of subarachnoid hemorrhage and intracerebral hemorrhage is a dominant cause of death and disability worldwide. Although great efforts have been made, the physiological mechanisms of these diseases are not fully understood and effective pharmacological interventions are still lacking. Melatonin (N-acetyl-5-methoxytryptamine), a neurohormone produced by the pineal gland, is a broad-spectrum antioxidant and potent free radical scavenger. More importantly, there is extensive evidence demonstrating that melatonin confers neuroprotective effects in experimental models of hemorrhagic stroke. Multiple molecular mechanisms such as antioxidant, anti-apoptosis, and anti-inflammation, contribute to melatonin-mediated neuroprotection against brain injury after hemorrhagic stroke. This review article aims to summarize current knowledge regarding the beneficial effects of melatonin in experimental models of hemorrhagic stroke and explores the underlying mechanisms. We propose that melatonin is a promising neuroprotective candidate that is worthy of further evaluation for its potential therapeutic applications in hemorrhagic stroke.

Study Type : Review

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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