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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Maize prolamins resistant to peptic-tryptic digestion maintain immune-recognition by IgA from some celiac disease patients.

Abstract Source:

Plant Foods Hum Nutr. 2012 Mar ;67(1):24, 30. PMID: 22298027

Abstract Author(s):

Francisco Cabrera-Chávez, Stefania Iametti, Matteo Miriani, Ana M Calderón de la Barca, Gianfranco Mamone, Francesco Bonomi

Article Affiliation:

Dipartimento di Scienze Molecolari Agroalimentari, Università degli Studi di Milano, Milano, Italy.

Abstract:

Maize is used as an alternative to wheat to elaborate food stuffs for celiac patients in a gluten-free diet.However, some maize prolamins (zeins) contain amino acid sequences that resemble the wheat gluten immunodominant peptides and their integrity after gastrointestinal proteolysisis unknown. In this study, the celiac IgA-immunoreactivity to zeins from raw or nixtamalized grains, before and after peptic/tryptic digestion was evaluated and their possible immunogenicity was investigated by in silico methods.IgA from some celiac patients with HLA-DQ2 or DQ8 haplotypes recognized two alpha-zeins even after peptic/ tryptic proteolysis. However, digestion affected zeins after denaturation, reduction, and alkylation, used for identification of prolamins as alpha-zein A20 and A30 by MS/MS sequencing. An in silico analysis indicated that other zeins contain similar sequences, or sequences that may bind even better to the HLA-DQ2/DQ8 molecules compared to the already identified ones. Results concur to indicate that relative abundance of these zeins, along with factors affecting their resistance to proteolysis, may be of paramount clinical relevance, and the use of maize in the formulation and preparation of gluten-free foods must be reevaluated in some cases of celiac disease.

Study Type : Human In Vitro

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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