Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

n/a
Abstract Title:

Lycopene prevents mitochondrial dysfunction during D-galactosamine/lipopolysaccharide induced fulminant hepatic failure in albino rats.

Abstract Source:

J Proteome Res. 2017 Jul 31. Epub 2017 Jul 31. PMID: 28758404

Abstract Author(s):

Sheik Abdulazeez Sheriff, Shaikhussain Shaik Ibrahim, Thiruvengadam Devaki, Sandipan Chakraborty, Subhash Agarwal, Horacio Perez-Sanchez

Article Affiliation:

Sheik Abdulazeez Sheriff

Abstract:

Fulminant hepatic failure (FHF) is a serious health issue, with a high mortality rate and characterized by severe perturbation in mitochondrial function. D-Galactosamine/lipopolysaccharide (D-GalN/LPS) induced FHF is a renowned model to evaluate the efficacy of hepatoprotective agents. Lycopene is an antioxidant and phytonutrient from carotenoid family. The health benefits of lycopene are prominent against cancer, cardiovascular, lung, liver, and skin problems. Recent studies have demonstrated the hepatoprotective, antidyslipidemic, and antioxidant roles of lycopene. In this context, the present study was designed to evaluate the ability of lycopene to prevent the mitochondrial dysfunction during the D-GalN/LPS induced FHF. The administration of D-GalN/LPS (300 mg and 30µg /kg body weight respectively) to the experimental rats induced several disturbances in mitochondrial function. The lipid and hydrogen peroxide levels were increased (p<0.05) with concomitant decrease in the activities of mitochondrial antioxidants, citric acid or tricarboxylic acid (TCA) cycle and electron transport chain enzymes. The cellular Adenosine triphosphate (ATP) content was also found to be decreased (p<0.05). lycopene (10 mg/kg body weight for 6 days) pretreatment attenuated lipid peroxidation and prohibited the excessive production of hydrogen peroxide. The D-GalN/LPS induced impairment in ATP production and increased enzyme activities were effectively prevented by the lycopene administration. The lycopene mediated mitochondrial protection was mainly ascribed to the strong antioxidant potential of this phytonutrient. Molecular modeling results obtained show evidence that lycopene inhibits several lipoxygenases provides rationale to the observed prevention of lipid peroxidation in the mitochondrial membrane. The carotenoid lycopene, combated oxidative stress, scavenged free radicals, prevented ROS generation, and inhibited the toxic effects of D-GalN/LPS during FHF.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.