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Depression: 21st Century Solutions + The Dark Side of Wheat

Article Publish Status: FREE
Abstract Title:

Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review.

Abstract Source:

Asian Pac J Cancer Prev. 2014 ;15(14):5501-8. PMID: 25081655

Abstract Author(s):

Ashok Kumar Pandurangan, Norhaizan Mohd Esa

Article Affiliation:

Ashok Kumar Pandurangan

Abstract:

Luteolin, 3', 4', 5,7-tetrahydroxyflavone, belongs to a group of naturally occurring compounds called flavonoids that are found widely in the plant kingdom. It possesses many beneficial properties including antioxidant, anti- inflammatory, anti-bacterial, anti-diabetic and anti-proliferative actions. Colorectal cancer (CRC) is a leading cause of cancer related deaths worldwide. Many signaling pathways are deregulated during the progression of colon cancer. In this review we aimed to analyze the protection offered by luteolin on colon cancer. During colon cancer genesis, luteolin known to reduce oxidative stress thereby protects the cell to undergo damage in vivo. Wnt/β-catenin signaling, deregulated during neoplastic development, is modified by luteolin. Hence, luteolin can be considered as a potential drug to treat CRC.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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