Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

500+ pages of Natural Medicine Alternatives and Information.

Abstract Title:

Long-term intake of white tea prevents oxidative damage caused by adriamycin in kidney of rats.

Abstract Source:

J Sci Food Agric. 2015 Oct 6. Epub 2015 Oct 6. PMID: 26441376

Abstract Author(s):

C Espinosa, J A López-Jiménez, F Pérez-Llamas, F A Guardiola, M A Esteban, M B Arnao, S Zamora

Article Affiliation:

C Espinosa

Abstract:

BACKGROUND: White tea infusion (Camelia sinensis) has antioxidants properties. Contains polyphenols that has been proposed to induced ARE response via NRF2. Adriamycin (ADR) has antitumor properties and oxidative effects. Oxidative stress is related with a variety of kidney diseases. Prevention of the oxidative stress through long-term intake of white tea and the study of the molecular mechanisms involved in protection could be of great interest. Rats were given distilled water, 0.015 or 0.045 g of solid white tea extract x kg(-1) body weight for 12 months. Animals received an injection of ADR. In kidney, oxidative stress parameters were measured, the expressions of nuclear factor E2-related factor 2 (Nrf2), and detoxifying and antioxidants genes were analysed, and the activities of CAT, SOD and GR were measured.

RESULTS: ADR administration increased oxidative parameters and decreased the antioxidant activity; significantly increased the expression of analysed genes and the activity of CAT and SOD and decreased GR activity. The highest white tea dose protected redox status and inhibited ARE response.

CONCLUSION: Long-term intake of white tea protected kidney against the oxidative stress. ADR activated the ARE response but in animals treated with the highest dose of white tea, this response was inhibited, probably for the antioxidant protection.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.