Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Elevated immune response in the brain of autistic patients.

Abstract Source:

J Neuroimmunol. 2009 Feb 15;207(1-2):111-6. Epub 2009 Jan 20. PMID: 19157572

Abstract Author(s):

Xiaohong Li, Abha Chauhan, Ashfaq M Sheikh, Sangita Patil, Ved Chauhan, Xiu-Min Li, Lina Ji, Ted Brown, Mazhar Malik

Abstract:

This study determined immune activities in the brain of ASD patients and matched normal subjects by examining cytokines in the brain tissue. Our results showed that proinflammatory cytokines (TNF-alpha, IL-6 and GM-CSF), Th1 cytokine (IFN-gamma) and chemokine (IL-8) were significantly increased in the brains of ASD patients compared with the controls. However the Th2 cytokines (IL-4, IL-5 and IL-10) showed no significant difference. The Th1/Th2 ratio was also significantly increased in ASD patients. Conclusion: ASD patients displayed an increased innate and adaptive immune response through the Th1 pathway, suggesting that localized brain inflammation and autoimmune disorder may be involved in the pathogenesis of ASD.

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Sayer Ji
Founder of GreenMedInfo.com

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Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

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