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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Investigation of the anti-obesity action of licorice flavonoid oil in diet-induced obese rats.

Abstract Source:

J Cardiovasc Pharmacol. 2008 Nov;52(5):452-458. PMID: 19060415

Abstract Author(s):

Hiroshi Kamisoyama, Kazuhisa Honda, Yuji Tominaga, Shinichi Yokota, Shin Hasegawa

Abstract:

Licorice flavonoid oil (LFO), which contains hydrophobic flavonoids from Glycyrrhiza glabra LINNE, is a new ingredient for functional foods. In this study, we investigated the anti-obesity action of LFO in diet-induced obese rats. The addition of 2% LFO in a high-fat diet significantly decreased the weight of abdominal adipose tissue and the levels of hepatic and plasma triglycerides. We found that the enzymatic activities of acetyl-CoA carboxylase and fatty acid synthase, the rate-limiting enzymes in the fatty acid synthetic pathway, were significantly decreased by LFO, whereas the enzymatic activity of acyl-CoA dehydrogenase, the rate-limiting enzyme in the fatty acid oxidative pathway, was significantly increased. All our findings suggest that the anti-obesity action of LFO is controlled by regulation of the rate-limiting enzymes in the fatty acid synthetic and oxidative pathways in the liver.

Study Type : Animal Study

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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