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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Lactobacillus plantarum MTCC 9510 supplementation protects from chronic unpredictable and sleep deprivation induced behaviour, biochemical and selected gut microbial aberrations in mice.

Abstract Source:

J Appl Microbiol. 2018 Mar 25. Epub 2018 Mar 25. PMID: 29575441

Abstract Author(s):

Jatinder Dhaliwal, Dhirendra Pratap Singh, Shashank Singh, P Anil Kumar, Ravneet Kaur Boparai, Mahendra Bishnoi, Kanthi Kiran Kondepudi, Kanwaljit Chopra

Article Affiliation:

Jatinder Dhaliwal

Abstract:

AIM: Here we evaluated any beneficial effects of a potential probiotic bacterial strain (Lactobacillus plantarum MTCC 9510) in two different stress paradigms in mice.

METHODS AND RESULTS: L. plantarum MTCC 9510 (2×10CFU per mice) was supplemented to male Swiss albino mice either subjected to chronic unpredictable mild stress or sleep deprivation stress. Various behavioral and biochemical tests along with selected gut bacterial abundances were determined. L. plantarum MTCC 9510 supplementation prevented stress-induced behavioral despair (depression, anxiety, learning and memory, stereotypic behavior), oxidative stress markers, and inflammatory cytokines in brain and serum. Its supplementation also improved gut and blood brain barrier integrity. It also affected cecal short chain fatty acids along with the promotion of Lactobacillus sp. and reduction of Enterobacteriaceae abundances. We also observed that two different stresses variably affected various behavioral and biochemical changes but L. plantarum MTCC 9510 supplementation most effectively prevented all these changes.

CONCLUSION: We provide evidence that positive modulation of the selected beneficial gut microbial population could serve as a viable strategy to neutralize day to day and sleep deprivation stress induced pathological alterations. This article is protected by copyright. All rights reserved.

Study Type : Animal Study

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Depression: 21st Century Solutions + The Dark Side of Wheat

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