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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

The involvement of neuroinflammation and necroptosis in the hippocampus during vascular dementia.

Abstract Source:

J Neuroimmunol. 2018 Jul 15 ;320:48-57. Epub 2018 Apr 17. PMID: 29759140

Abstract Author(s):

Mourad Belkhelfa, Narimene Beder, Daya Mouhoub, Manel Amri, Rafa Hayet, Nabila Tighilt, Souad Bakheti, Soraya Laimouche, Djamel Azzouz, Rachid Belhadj, Chafia Touil-Boukoffa

Article Affiliation:

Mourad Belkhelfa

Abstract:

The prevalence of vascular dementia is increasing at an alarming rate. The Confirmation of the clinical diagnosis of vascular dementia depends on post-mortem examination of the brain. In our study, we investigated the vascular disease and neuroinflammation during vascular dementia. Our results showed aβ-amyloid deposits, neovascularization, neuronal hypertrophy and neuroinflammation in the hippocampus tissue. Interestingly, the neuroinflammation was characterized by a higher expression of TNF-α, IL-1β, TGF-β and iNOS which are TLR4/RelA pathway dependent. Finally, the finding of necroptosis by impaired blood supply and inflammation state suggests that the cognitive impairment was caused by vascular disease and neuroinflammation.

Study Type : In Vitro Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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