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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Indole-3-carbinol improves neurobehavioral symptoms in a cerebral ischemic stroke model.

Abstract Source:

Naunyn Schmiedebergs Arch Pharmacol. 2018 06 ;391(6):613-625. Epub 2018 Mar 30. PMID: 29602953

Abstract Author(s):

Pankaj Paliwal, Gaurav Chauhan, Deepa Gautam, Debabrata Dash, Shashikant C U Patne, Sairam Krishnamurthy

Article Affiliation:

Pankaj Paliwal

Abstract:

Stroke is one of the most common causes of death worldwide and also responsible for permanent disability. Ischemic stroke has been found to affect 80% of stroke patients. Recombinant tissue plasminogen activator (rtPA) is the widely used drug for the ischemic stroke with narrow therapeutic window. Indole-3-carbinol (I3C) is a natural compound obtained from brassica species having antithrombotic activity. Middle cerebral artery occlusion (MCAO) model was used followed by reperfusion after 2 h of ischemia for the evaluation of the I3C against ischemic stroke. After reperfusion, I3C (12.5, 25, and 50 mg/kg) was given by oral route once daily and continued up to the 14th day. Behavioral studies including postural reflex, forelimb placing, and cylinder tests showed I3C attenuated the MCAO-induced increase in average score and asymmetry score efficiently. Mean cerebral blood flow (CBF) was improved by treatment with I3C (12.5 mg/kg) by 60% of baseline at 6 h. I3C inhibited ADP-induced platelet aggregation and reduced ischemic volume significantly. It also inhibited in vitro the ADP-induced platelet aggregation in healthy human volunteers. I3C improves behavioral scores and mean CBF after focal cerebral ischemia in rats. Furthermore, I3C showed prophylactic anti-thrombotic activity against carrageenan induced tail thrombosis. Therefore, preclinical evidence points to I3C asa potential candidate for use in cerebral ischemic stroke.

Study Type : Animal Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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