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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Clinical assessment of patients with recalcitrant psoriasis in a randomized, observer-blind, vehicle-controlled trial using indigo naturalis.

Abstract Source:

Arch Dermatol. 2008 Nov;144(11):1457-64. PMID: 19015420

Abstract Author(s):

Yin-Ku Lin, Chee-Jen Chang, Ya-Ching Chang, Wen-Rou Wong, Shu-Chen Chang, Jong-Hwei Su Pang

Abstract:

OBJECTIVE: To evaluate the efficacy and safety of treatment with indigo naturalis in patients with recalcitrant plaque-type psoriasis. DESIGN: Randomized, observer-blind, vehicle-controlled, intrapatient comparison study. SETTING: Ambulatory department of a hospital. PARTICIPANTS: Forty-two outpatients with chronic plaque psoriasis were enrolled in the study from May 1, 2004, to April 30, 2005. INTERVENTION: The patients applied either indigo naturalis ointment or vehicle ointment topically to each of 2 bilaterally symmetrical psoriatic plaque lesions for 12 weeks (depending on the date of enrollment in the study). MAIN OUTCOME MEASURES: The outcomes were assessed using the following criteria: the sum of erythema, scaling, and induration scores and the clearing percentage of the target plaque lesion assessed by 2 blinded observers. RESULTS: Significant reductions in the sum of scaling, erythema, and induration scores (P < .001) (mean score, 6.3 after indigo naturalis treatment vs 12.8 in control subjects) and plaque area percentage (P < .001) (mean percentage, 38.5% after indigo naturalis treatment vs 90% in controls) were achieved with topical application of indigo naturalis ointment. Approximately 31 of 42 patients (74%) experienced clearance or near clearance of their psoriasis in the indigo ointment-treated lesion. CONCLUSION: Topical indigo naturalis ointment was a novel, safe, and effective therapy for plaque-type psoriasis.

Study Type : Human Study
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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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