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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

High serum levels of malondialdehyde and antioxidant enzymes are associated with post-stroke anxiety.

Abstract Source:

Neurol Sci. 2018 Jun ;39(6):999-1007. Epub 2018 Mar 6. PMID: 29511963

Abstract Author(s):

Zhihua Liu, Yan Cai, Xingru Zhang, Zhuoying Zhu, Jincai He

Article Affiliation:

Zhihua Liu

Abstract:

Post-stroke anxiety (PSA) is a common neuropsychiatric affective disorder occurring after stroke. The purpose of this study was to investigate the association between anxiety and the serum levels of oxidative stress markers at admission. First-ever or recurrent ischemic stroke patients were consecutively recruited into the study and followed up 1 month. Patients were divided into PSA and non-PSA group according DSM-IV criteria for anxiety due to stroke. Overall, 49 patients (24.1%) were diagnosed anxiety. Serum GPX (glutathione peroxidase), CAT (catalase), SOD (superoxide dismutase), and MDA (malondialdehyde) were significantly higher in patients with anxiety than patients without anxiety. The HAM-A scores had a significant positive association with MDA levels. In multivariate logistic regression analysis, serum antioxidant enzymes and MDA were independent predictors of PSA. An increased risk of PSA was associated with serum MDA levels ≥ 3.0 nmol/ml (adjusted OR 8.68, 95% CI 3.02-24.95; P < 0.001) after adjusting for relevant confounders such as social support and treatments at admission. Elevated serum levels of lipid oxidation products and antioxidant enzymes at admission were associated with anxiety 1 month after stroke, suggesting that these alterations might participate in thepathophysiology of anxiety symptoms in stroke patients.

Study Type : Human Study

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Depression: 21st Century Solutions + The Dark Side of Wheat

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